Antiplatelet antibodies and platelet counts in pregnancies complicated by autoimmune thrombocytopenic purpura
| Autor: | N. S. Rote, Dwight P. Cruikshank, James R. Scott |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Blood Platelets
medicine.medical_specialty Amniotic fluid medicine.medical_treatment Splenectomy Autoimmune thrombocytopenic purpura Gastroenterology Infant Newborn Diseases Neonatal Thrombocytopenia Autoimmune Diseases Adrenal Cortex Hormones Pregnancy Internal medicine Diseases in Twins Twins Dizygotic medicine Humans Platelet Maternal-Fetal Exchange Autoantibodies Fetus Scalp biology Cesarean Section Platelet Count business.industry Pregnancy Complications Hematologic Infant Newborn Obstetrics and Gynecology Amniotic Fluid medicine.anatomical_structure Purpura Thrombocytopenic Immunology biology.protein Female Antibody business |
| Zdroj: | American Journal of Obstetrics and Gynecology. 145:932-935 |
| ISSN: | 0002-9378 |
| DOI: | 10.1016/0002-9378(83)90843-8 |
| Popis: | In 48 pregnant women with autoimmune thrombocytopenic purpura, no consistent correlation was found between the infant platelet count and either the maternal platelet count, a previous maternal splenectomy, or maternal treatment with corticosteroids. Although the concentration of antiplatelet antibody in maternal serum frequently reflected the severity of neonatal thrombocytopenia, a number of exceptions to this observation limited the clinical usefulness of the test for individual patients. Antiplatelet antibody levels in the amniotic fluid were always low. A twin gestation in this series of patients in which one infant was thrombocytopenic and the other was not also showed that no antepartum maternal clinical characteristic or laboratory test can accurately predict the fetal platelet count. Only fetal platelet counts from scalp samples obtained prior to or early in labor from 25 patients with autoimmune thrombocytopenic purpura proved to be reliable in assessing the degree of fetal thrombocytopenia and selecting the appropriate route of delivery. |
| Databáze: | OpenAIRE |
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