Accuracy of Valproic Acid Concentration Correction Based on Serum Albumin

Autor: Aulbrey Drisaldi, Nicholas Orvin, Zeke Campbell, Nicole Bohm, Ron Neyens, Erin R. Weeda, Leonardo Bonilha
Rok vydání: 2018
Předmět:
Zdroj: Neurocritical Care. 30:301-306
ISSN: 1556-0961
1541-6933
DOI: 10.1007/s12028-018-0627-4
Popis: Patient-specific factors can alter the pharmacokinetic disposition of valproic acid. Specifically, the free fraction of valproic acid can increase substantially in patients with hypoalbuminemia or as serum drug concentrations rise due to saturable protein binding. Direct measurement of free serum drug concentrations allows for accurate assessment of drug levels, but the assay may not be readily available in all institutions. The effect of hypoalbuminemia on free fraction has been quantified and serves as the basis of an equation used to “correct” measured total valproic acid concentrations. The aim of this study was to evaluate the accuracy of the equation. This retrospective study included adult patients with measurable free and total valproic acid concentrations between July 2014 and June 2017. The primary aim was to assess the relationship between measured and predicted free valproic acid concentrations. Free levels were categorized as subtherapeutic, therapeutic, or supratherapeutic based on the reference range of 7–23 mg/L. Concordance was defined as measured and predicted concentrations falling within the same category. The analysis included 174 patients with a median age of 58 years and a median albumin of 3 g/dL. The majority of patients were hospitalized (88.5%). Concordance occurred in 56.9% of samples. A Spearman’s correlation coefficient of 0.60 (p
Databáze: OpenAIRE
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