Association between MICA rs2596542 Polymorphism with the Risk of Hepatocellular Carcinoma in Chronic Hepatitis C Patients
| Autor: | Rafael Tomoya Michita, Daniel Simon, Deivid Cruz dos Santos, Mário Reis Álvares-da-Silva, Jóice Teixeira de Bitencorte, Vagner Ricardo Lunge, Camila Guerra Marangon |
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| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine Cancer Research medicine.medical_specialty Carcinoma Hepatocellular Cirrhosis Genotype Single-nucleotide polymorphism Polymorphism Single Nucleotide Gastroenterology Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine Internal medicine Humans Medicine SNP Genetic Predisposition to Disease Clinical significance Aged business.industry Histocompatibility Antigens Class I Liver Neoplasms virus diseases General Medicine Odds ratio Hepatitis C Chronic Middle Aged medicine.disease digestive system diseases Genotype frequency 030104 developmental biology Oncology 030220 oncology & carcinogenesis Hepatocellular carcinoma Female business Brazil |
| Zdroj: | Pathology & Oncology Research. 26:1519-1525 |
| ISSN: | 1532-2807 1219-4956 |
| DOI: | 10.1007/s12253-019-00738-6 |
| Popis: | In this study we investigated the impact of rs2596542A/G single nucleotide polymorphism (SNP) in the major histocompatibility complex class I chain-related sequence A (MICA) gene on HCV-induced hepatocellular carcinoma (HCC) susceptibility in a Brazilian population. In total, 252 HCV-infected patients (98 with HCV-induced HCC and 154 non-malignant HCV-induced liver cirrhosis) were enrolled and 98 healthy control subjects (negative anti-HCV). The MICA rs2596542 SNP genotypes were determined by real-time PCR assay. No differences in MICA genotype frequencies between HCV-induced cirrhosis patients and controls were observed. However, genotype frequencies of rs2596542A/G SNP were statistically different between HCV-induced HCC patients and controls (p = 0.048), and also between HCC and HCV-induced cirrhosis patients (p = 0.039). The highest frequency of the rs2596542AA genotype was observed in HCC patients (31.6%) when compared with HCV-induced cirrhosis patients (18.8%) and healthy controls (19.4%). Also, rs2596542AA genotype carriers have an increased risk for HCC when compared to HCV-induced cirrhosis status [odds ratio (OR) = 1.99; 95% confidence interval (CI) = 1.06-3.74, p = 0.020)] and healthy individuals (OR = 1.92, 95% CI = 1.00-3.70, p = 0.049). Taken together our study suggest that MICA rs2596542 SNP impacts HCV-induced HCC susceptibility suggesting that genetic variants in MICA are of clinical relevance to hepatocarcinogenesis by impacting host immune response in chronic HCV infection. |
| Databáze: | OpenAIRE |
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