Small-molecule inhibitors of the PI3K signaling network
| Autor: | Alexei Degterev, Colleen Mcnamara |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Pharmacology
Effector Proto-Oncogene Proteins c-akt Small Molecule Libraries Cell migration Biology Article Cell biology Pleckstrin homology domain Phosphatidylinositol 3-Kinases Drug development Drug Discovery Animals Humans Molecular Medicine Enzyme Inhibitors Signal transduction PI3K/AKT/mTOR pathway Phosphoinositide-3 Kinase Inhibitors Signal Transduction |
| Zdroj: | Future Medicinal Chemistry. 3:549-565 |
| ISSN: | 1756-8927 1756-8919 |
| DOI: | 10.4155/fmc.11.12 |
| Popis: | The phosphoinositide 3-kinase (PI3K) signaling pathway controls a wide variety of cellular processes including cell death and survival, cell migration, protein synthesis and metabolism. Aberrant PI3K-dependent signaling, mediated by Akt kinase, has been implicated in many human diseases including cancer, inflammation, cardiovascular disease and metabolic diseases, making this pathway a principle target for drug development. In this article we will summarize the PI3K signaling network and discuss current strategies for pathway inhibition. We will also explore the importance and emerging relevance of Akt-independent PI3K signaling pathways and discuss attempts being made to harness these pathways by inhibiting the binding of a product of PI3K, phosphatidylinositol-(3,4,5)-trisphosphate, to effector pleckstrin homology domains. |
| Databáze: | OpenAIRE |
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