Nonviral infection-related lymphocytopenia for the prediction of adult sepsis and its persistence indicates a higher mortality
| Autor: | Jie Jiang, Yanxin Su, Bai-Lin Niu, Meihao Chen, Hui-Min Du, Xin Li, Guosheng Ren, Fa-Ming He, Jing Zhang |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
medicine.medical_specialty Neutrophils Observational Study Gastroenterology Procalcitonin Sepsis sepsis 03 medical and health sciences Leukocyte Count 0302 clinical medicine White blood cell Internal medicine Lymphopenia medicine Humans 030212 general & internal medicine Lactic Acid Aged Retrospective Studies predict business.industry Mortality rate Area under the curve General Medicine Middle Aged medicine.disease mortality medicine.anatomical_structure Early Diagnosis ROC Curve lymphocytopenia 030220 oncology & carcinogenesis Area Under Curve Absolute neutrophil count Biomarker (medicine) Lymphocytopenia business diagnose Biomarkers Research Article |
| Zdroj: | Medicine |
| ISSN: | 1536-5964 |
| Popis: | Sepsis is a life-threatening disease that affects 30 million people worldwide each year. Despite the rapid advances in medical technology and organ support systems, it is still difficult to reduce the mortality rate. Early and rapid diagnosis is crucial to improve the treatment outcome. The aim of this study was to investigate the prediction efficiency of lymphopenia and other clinical markers, such as white blood cell (WBC), neutrophil count (N#), procalcitonin (PCT), and arterial lactic acid (Lac) in the diagnosis and prognosis assessment for adult patients with nonviral infection-related sepsis. A total of 77 sepsis- and 23 non-sepsis adult patients were enrolled in this study from September 2016 to September 2018. Daily lymphocyte count (Lym) of the patients was calculated until discharge or death. The diagnostic performance of the Lym and other biomarkers were compared using the area under the receiver operating characteristic curve (ROC) value. The level of Lym was decreased significantly in the sepsis group. Lym had a high diagnostic performance for sepsis, with an area under the curve (AUC) value of 0.971 (95% CI = 0.916–0.994). The diagnostic efficacy of Lym was more significant than WBC, N#, and PCT (P 3 days indicates a higher 28-day mortality rate. |
| Databáze: | OpenAIRE |
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