In vitro genotoxicity and cytotoxicity of polydopamine-coated magnetic nanostructures
| Autor: | Karol Załęski, Bartosz F. Grześkowiak, Radosław Mrówczyński, Anna Woźniak, Emerson Coy, Magdalena Walawender, Dominika Tempka |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Indoles Biocompatibility Polymers Solvothermal synthesis Nanotechnology Apoptosis 02 engineering and technology Toxicology medicine.disease_cause Nanomaterials Nanoclusters Cell Line 03 medical and health sciences Microscopy Electron Transmission Cell Line Tumor Spectroscopy Fourier Transform Infrared medicine Humans Cytotoxicity Magnetite Nanoparticles Chemistry Magnetic Phenomena General Medicine 021001 nanoscience & nanotechnology Oxidative Stress 030104 developmental biology Polymerization Magnetic nanoparticles 0210 nano-technology Reactive Oxygen Species Genotoxicity DNA Damage |
| Zdroj: | Toxicology in vitro : an international journal published in association with BIBRA. 44 |
| ISSN: | 1879-3177 |
| Popis: | Synthesis of magnetic nanoparticles and magnetic nanoclusters was performed by the co-precipitation method or solvothermal synthesis, respectively, followed by oxidative polymerization of dopamine, resulting in a polydopamine (PDA) shell. The nanomaterials obtained were described using TEM, FTIR and magnetic measurements. For the first time, cyto- and genotoxicity studies of polydopamine-coated nanostructures were performed on cancer and normal cell lines, providing in-depth insight into the toxicity of such materials. The tests conducted, e.g. ROS, apoptosis and DNA double-break of the nanomaterials obtained revealed the low toxicity of these structures. Thus, these results prove the biocompatibility and low genotoxicity of these materials and provide new data on the toxicity of PDA-coated materials, which is of great importance for their biomedical application. |
| Databáze: | OpenAIRE |
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