Comparison of nucleoside and nucleotide analogs in the recurrence of hepatitis B virus‐related hepatocellular carcinoma after surgical resection: A multicenter study

Autor: Weili Qi, Chuan Li, Wei Peng, Junlong Dai, Shun Ran, Junyi Shen, Yu Zhang, Shusheng Leng, Tian-Fu Wen, Youwei Wu, Xiaoyun Zhang, Fengwei Gao
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Cancer Research
medicine.medical_specialty
Carcinoma
Hepatocellular
Guanine
recurrence
medicine.medical_treatment
Subgroup analysis
medicine.disease_cause
Antiviral Agents
Gastroenterology
Internal medicine
Hepatectomy
Humans
Medicine
Radiology
Nuclear Medicine and imaging
resection
Tenofovir
Research Articles
RC254-282
Retrospective Studies
Hepatitis B virus
Nucleotides
business.industry
Liver Neoplasms
Hazard ratio
Clinical Cancer Research
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Nucleosides
Entecavir
hepatocellular carcinoma
Middle Aged
Hepatitis B
Prognosis
medicine.disease
Survival Analysis
digestive system diseases
nucleos(t)ide analogs
Oncology
Hepatocellular carcinoma
Propensity score matching
Female
Neoplasm Recurrence
Local
business
hepatitis B virus
Research Article
medicine.drug
Zdroj: Cancer Medicine, Vol 10, Iss 23, Pp 8421-8431 (2021)
Cancer Medicine
ISSN: 2045-7634
Popis: Background Antiviral therapy should reduce the recurrence of hepatitis B virus‐related hepatocellular carcinoma (HBV‐related HCC) after surgical resection. However, there is little research on whether various antiviral drugs have different prognostic effects in patients with HBV‐related HCC after curative liver resection. The present study compared the effects of nucleotide analog (NtA) and nucleoside analog (NsA) antiviral therapies after surgical resection on the prognosis of HBV‐related HCC. Methods A total of 1303 patients with HBV‐related HCC who received curative hepatectomy at five institutes between April 2014 and April 2019 were retrospectively enrolled and analyzed. Propensity matching analysis was used to compare the outcomes of HCC patients given NsA versus NtA therapy. Subgroup analysis of patients treated with entecavir (ETV) and tenofovir disoproxil fumarate (TDF) was also performed. Results Among 1303 patients, 759 (58.2%) patients developed recurrence, and 460 (35.3%) patients died. Multivariable analyses revealed that NtA therapy significantly decreased the risk of HCC recurrence (hazard ratio [HR], 0.64; 95% confidence interval [CI], 0.51–0.80; p
The aim of this study was to investigate the effect of antiviral drug on the prognosis of hepatitis B virus‐related hepatocellular carcinoma (HCC) after curative hepatectomy. We found that nucleotide analog treatment, rather than nucleoside analog treatment, significantly reduced HCC recurrence and improved overall survival after curative hepatic resection.
Databáze: OpenAIRE
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