Parental occupational exposure to low-frequency magnetic fields and risk of leukaemia in the offspring: findings from the Childhood Leukaemia International Consortium (CLIC)
Autor: | Alice Kang, John D Dockerty, Olli Lohi, Madar Talibov, Theodora Psaltopoulou, Eleni Petridou, Ann Olsson, Eve Roman, Javier Vila, Lucia Miligi, Catherine Metayer, Logan G. Spector, Elisabeth Cardis, Friederike Erdmann, Jacqueline Clavel, Anssi Auvinen, Corrado Magnani, Helen D. Bailey, Joachim Schüz, Atte Nikkilä |
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Přispěvatelé: | Lääketieteen ja terveysteknologian tiedekunta - Faculty of Medicine and Health Technology, Yhteiskuntatieteiden tiedekunta - Faculty of Social Sciences, Tampere University |
Rok vydání: | 2019 |
Předmět: |
Male
Oncology elf-mf medicine.medical_specialty Adolescent Childhood leukemia Kansanterveystiede ympäristö ja työterveys - Public health care science environmental and occupational health Offspring case-control study acute lymphoblastic leukemia acute myeloid leukemia Logistic regression 03 medical and health sciences 0302 clinical medicine Pregnancy hemic and lymphatic diseases Occupational Exposure Internal medicine occupation medicine Humans Child Workplace 030304 developmental biology 0303 health sciences business.industry Public Health Environmental and Occupational Health Case-control study Infant Precursor Cell Lymphoblastic Leukemia-Lymphoma medicine.disease Childhood leukaemia Leukemia Myeloid Acute Magnetic Fields Maternal Exposure Case-Control Studies Child Preschool Prenatal Exposure Delayed Effects 030220 oncology & carcinogenesis Paternal Exposure Female Occupational exposure Myeloid leukaemia business |
Zdroj: | Occupational and Environmental Medicine |
ISSN: | 1470-7926 1351-0711 |
DOI: | 10.1136/oemed-2019-105706 |
Popis: | ObjectivesPreviously published studies on parental occupational exposure to extremely low-frequency magnetic fields (ELF-MF) and risk of acute lymphoblastic leukaemia (ALL) and acute myeloid leukaemia (AML) in their offspring were inconsistent. We therefore evaluated this question within the Childhood Leukemia International Consortium.MethodsWe pooled 11 case–control studies including 9723 childhood leukaemia cases and 17 099 controls. Parental occupational ELF-MF exposure was estimated by linking jobs to an ELF-MF job-exposure matrix (JEM). Logistic regression models were used to estimate ORs and 95% CIs in pooled analyses and meta-analyses.ResultsORs from pooled analyses for paternal ELF-MF exposure >0.2 microtesla (µT) at conception were 1.04 (95% CI 0.95 to 1.13) for ALL and 1.06 (95% CI 0.87 to 1.29) for AML, compared with ≤0.2 µT. Corresponding ORs for maternal ELF-MF exposure during pregnancy were 1.00 (95% CI 0.89 to 1.12) for ALL and 0.85 (95% CI 0.61 to 1.16) for AML. No trends of increasing ORs with increasing exposure level were evident. Furthermore, no associations were observed in the meta-analyses.ConclusionsIn this large international dataset applying a comprehensive quantitative JEM, we did not find any associations between parental occupational ELF-MF exposure and childhood leukaemia. |
Databáze: | OpenAIRE |
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