Parental occupational exposure to low-frequency magnetic fields and risk of leukaemia in the offspring: findings from the Childhood Leukaemia International Consortium (CLIC)

Autor: Alice Kang, John D Dockerty, Olli Lohi, Madar Talibov, Theodora Psaltopoulou, Eleni Petridou, Ann Olsson, Eve Roman, Javier Vila, Lucia Miligi, Catherine Metayer, Logan G. Spector, Elisabeth Cardis, Friederike Erdmann, Jacqueline Clavel, Anssi Auvinen, Corrado Magnani, Helen D. Bailey, Joachim Schüz, Atte Nikkilä
Přispěvatelé: Lääketieteen ja terveysteknologian tiedekunta - Faculty of Medicine and Health Technology, Yhteiskuntatieteiden tiedekunta - Faculty of Social Sciences, Tampere University
Rok vydání: 2019
Předmět:
Male
Oncology
elf-mf
medicine.medical_specialty
Adolescent
Childhood leukemia
Kansanterveystiede
ympäristö ja työterveys - Public health care science
environmental and occupational health

Offspring
case-control study
acute lymphoblastic leukemia
acute myeloid leukemia
Logistic regression
03 medical and health sciences
0302 clinical medicine
Pregnancy
hemic and lymphatic diseases
Occupational Exposure
Internal medicine
occupation
medicine
Humans
Child
Workplace
030304 developmental biology
0303 health sciences
business.industry
Public Health
Environmental and Occupational Health

Case-control study
Infant
Precursor Cell Lymphoblastic Leukemia-Lymphoma
medicine.disease
Childhood leukaemia
Leukemia
Myeloid
Acute

Magnetic Fields
Maternal Exposure
Case-Control Studies
Child
Preschool

Prenatal Exposure Delayed Effects
030220 oncology & carcinogenesis
Paternal Exposure
Female
Occupational exposure
Myeloid leukaemia
business
Zdroj: Occupational and Environmental Medicine
ISSN: 1470-7926
1351-0711
DOI: 10.1136/oemed-2019-105706
Popis: ObjectivesPreviously published studies on parental occupational exposure to extremely low-frequency magnetic fields (ELF-MF) and risk of acute lymphoblastic leukaemia (ALL) and acute myeloid leukaemia (AML) in their offspring were inconsistent. We therefore evaluated this question within the Childhood Leukemia International Consortium.MethodsWe pooled 11 case–control studies including 9723 childhood leukaemia cases and 17 099 controls. Parental occupational ELF-MF exposure was estimated by linking jobs to an ELF-MF job-exposure matrix (JEM). Logistic regression models were used to estimate ORs and 95% CIs in pooled analyses and meta-analyses.ResultsORs from pooled analyses for paternal ELF-MF exposure >0.2 microtesla (µT) at conception were 1.04 (95% CI 0.95 to 1.13) for ALL and 1.06 (95% CI 0.87 to 1.29) for AML, compared with ≤0.2 µT. Corresponding ORs for maternal ELF-MF exposure during pregnancy were 1.00 (95% CI 0.89 to 1.12) for ALL and 0.85 (95% CI 0.61 to 1.16) for AML. No trends of increasing ORs with increasing exposure level were evident. Furthermore, no associations were observed in the meta-analyses.ConclusionsIn this large international dataset applying a comprehensive quantitative JEM, we did not find any associations between parental occupational ELF-MF exposure and childhood leukaemia.
Databáze: OpenAIRE