A screen of pharmaceutical drugs for their ability to cause short-term morbidity and mortality in the common bed bug, Cimex lectularius L
| Autor: | Gale E. Ridge, Mayur Vallabhaneni, Wenjing Du, Nikhil Mallipeddi, Johnathan M. Sheele |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Drug Bedbugs Insecticides Primaquine media_common.quotation_subject 030231 tropical medicine 030106 microbiology Population Pilot Projects Pharmacology 03 medical and health sciences 0302 clinical medicine Ivermectin Bed bug medicine Animals Humans education Ethambutol media_common education.field_of_study Sheep General Veterinary biology General Medicine biology.organism_classification Fecundity Fertility Infectious Diseases Insect Science Female Parasitology Cimex lectularius medicine.drug |
| Zdroj: | Parasitology Research. 116:2619-2626 |
| ISSN: | 1432-1955 0932-0113 |
| DOI: | 10.1007/s00436-017-5565-0 |
| Popis: | The common bed bug, Cimex lectularius L., is a hematophagous ectoparasite that preferentially feeds on humans. Pharmaceuticals present in a person’s blood may adversely affect C. lectularius when it feeds. We fed >10,000 C. lectularius on blood samples containing more than 400 different drug doses and drug combinations using an in vitro feeding system to determine insect mortality. The majority of drug doses approximated the peak plasma concentration in humans taking those drugs. Twenty-one drugs were found to cause >17% 12–14-day mortality compared to 8.5% mortality in the control (p |
| Databáze: | OpenAIRE |
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