Tallness is associated with risk of testicular cancer: evidence for the nutrition hypothesis
| Autor: | Johannes Classen, Pichlmeier U, Lüdde R, Diederichs M, Klaus-Peter Dieckmann, Hartmann Jt |
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| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Pediatrics Adolescent Epidemiology Short stature Body Mass Index BMI non-seminoma Testicular Neoplasms Risk Factors Internal medicine childhood nutrition medicine Humans Testicular cancer business.industry seminoma Case-control study Odds ratio Seminoma Neoplasms Germ Cell and Embryonal medicine.disease Confidence interval Body Height testicular cancer Endocrinology Logistic Models Oncology El Niño Case-Control Studies medicine.symptom business body size Energy Intake Body mass index |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| Popis: | The pathogenesis of testicular germ cell tumours (GCTs) is potentially influenced by high-energy nutrition during infancy. As adult height is a proxy for childhood nutrition, we investigated the role of nutrition in GCT pathogenesis by comparing stature of patients with healthy men. In a matched case-control study, 6415 patients with GCT were compared with healthy army conscripts (1:6 matching modus) with regard to height (cm) and body mass index (BMI; kg/m(2)). Statistical analysis involved tabulation of descriptive height measures and BMI. Conditional logistic regression models were used to quantify the association of GCT with height, with odds ratios (OR) adjusted for BMI. The literature was searched for studies on stature in GCT patients. Body size is significantly associated with risk of GCT, very tall men (>195 cm) having a GCT risk of OR=3.35 (95% confidence intervals (CI): 2.88-3.90; adjusted). Short stature is protective (OR=0.798; 95% CI: 0.68-0.93). Both histologic subgroups are associated with tallness. Of 16 previous reports, 7 were confirmative, 5 had null and 4 equivocal results. The association of stature with GCT risk accords with the nutrition hypothesis of GCT. This study expands the current view of GCT tumorigenesis by suggesting that high-calorie intake in childhood promotes GCT precursors originating in utero. |
| Databáze: | OpenAIRE |
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