Music exposure attenuates anxiety- and depression-like behaviors and increases hippocampal spine density in male rats
| Autor: | George Panagis, A. Papadakakis, Kyriaki Sidiropoulou |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
Elevated plus maze medicine.medical_specialty Dendritic spine Dendritic Spines Neurogenesis Hippocampus Hippocampal formation Anxiety Rats Sprague-Dawley 03 medical and health sciences Behavioral Neuroscience 0302 clinical medicine Internal medicine Neuroplasticity Medicine Animals 030304 developmental biology 0303 health sciences Environmental enrichment Depressive Disorder Neuronal Plasticity Behavior Animal business.industry Depression Maternal Deprivation Brain Anxiety Disorders Rats Disease Models Animal Endocrinology Animals Newborn Exploratory Behavior Female medicine.symptom business 030217 neurology & neurosurgery Music Stress Psychological Behavioural despair test |
| Zdroj: | Behavioural brain research. 372 |
| ISSN: | 1872-7549 |
| Popis: | Epidemiological and clinical studies suggest that early-life stress (ELS) may lead to the development of mental disorders in adulthood. Maternal separation (MS) is a valid animal model of ELS that produces detrimental effects on brain and behavior of experimental animals. Positive environmental stimuli have been shown to counteract the behavioral deficits of ELS and enhance neuroplasticity. Recent data indicate that music may serve as a form of environmental enrichment in experimental animals. However, the underlying mechanisms through which musical enrichment exerts its effects are poorly understood. Male Sprague–Dawley rats were submitted to a 3 h MS protocol during postnatal days (PND) 2–14, while another group was left undisturbed. Half of the animals within each group were exposed from PND 21 to PND 76 for 12 h/day to Mozart K. 448. At approximately three months of age, elevated plus maze procedure, forced swim test and social approach task were applied to test whether music exposure can mitigate the effects of MS stress on animal emotional behaviors. Moreover, we investigated the effects of these treatments on dendritic spine density in the CA1 region of hippocampus. As expected, MS rats showed decreased sociability, increased anxiety- and depressive-like behaviors, and decreased mature dendritic spines in the CA1 region of hippocampus in adulthood. Musical enrichment reversed these effects. Our results suggest that musical enrichment can reverse the negative effects of MS on anxiety, depression, and sociability in adult rats and modulate neuronal plasticity and provide additional data for a new therapeutic intervention to rescue emotional symptoms. |
| Databáze: | OpenAIRE |
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