Impaired Ketogenesis in Iron-Deficient Rat Pups
| Autor: | Adria Rothman Sherman, Sandra J. Bartholmey |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Vitamin
Aging medicine.medical_specialty Medicine (miscellaneous) Mitochondria Liver Ketone Bodies Mitochondrion Biology chemistry.chemical_compound Pregnancy Carnitine Lactation Internal medicine Ketogenesis medicine Iron deficient Animals Ferrous Compounds Triglycerides Nutrition and Dietetics Rats Inbred Strains Iron Deficiencies Metabolism Animals Suckling Rats Endocrinology medicine.anatomical_structure Liver chemistry Ketone bodies Female medicine.drug |
| Zdroj: | The Journal of Nutrition. 116:2180-2189 |
| ISSN: | 0022-3166 |
| Popis: | Livers of Fe-deficient rat pups contain significantly less carnitine and more triacylglycerol (TG) than livers of control pups. Carnitine affects ketogene- sis (KG), which is a vital adaptation in the neonate. To determine if KG is impaired by low carnitine in Fe-deficient pup liver, ketone body synthesis was measured in liver mitochondria from 15-d-old pups. Litters from Fe-deficient ( â€" Fe) and Fe-adequate ( + Fe) dams were orally supplemented with water (W) as a control, 18 mMferrous sulfate, or 10 mM L-carnitine from d 8 through d 15 of lactation. The amount of ketone bodies (AŸ-hydroxybutyrate + acetoacetate) synthesized was 68 % less (P < 0.05) in â€" FeW pups than in +FeW pups. Iron or carnitine supplementation in creased KG in - Fe pups to + Fe KG levels, but carnitine did not affect KG in + Fe pups. Liver TG in + Fe pups was not altered by supplementation, but liver TG was lowered in - Fe pups by carnitine and iron 21% and 64 %, respectively, compared to - FeW pups. The data support the hypothesis that in the Fe-deficient suckling rat, low carnitine levels may contribute to impaired ketogenesis and increased lipids in liver. J. Nutr. 116: 2180-2189, 1986. |
| Databáze: | OpenAIRE |
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