Expression of Ets-1 proto-oncoprotein in gastrointestinal stromal tumors, leiomyomas and schwannomas
| Autor: | Ayumi Yoshizaki, Gabit Alipov, Chun Yang Wen, Yuichi Yakata, Shinji Naito, Toshiyuki Nakayama, Ichiro Sekine |
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| Rok vydání: | 2006 |
| Předmět: |
Pathology
medicine.medical_specialty Stromal cell Gastrointestinal Stromal Tumors Biology Surgical pathology Proto-Oncogene Protein c-ets-1 medicine Biomarkers Tumor Humans neoplasms Cell Proliferation Gastrointestinal Neoplasms Gastrointestinal tract Leiomyoma Mesenchymal stem cell Gastroenterology General Medicine University hospital medicine.disease Immunohistochemistry female genital diseases and pregnancy complications digestive system diseases Cell Transformation Neoplastic Clinical risk factor Neurilemmoma Rapid Communication |
| Zdroj: | World journal of gastroenterology. 12(11) |
| ISSN: | 1007-9327 |
| Popis: | AIM: Gastrointestinal stromal tumors (GISTs) are rare. GISTs differ from other mesenchymal tumors of the gastrointestinal tract (e.g. leiomyomas and schwannomas). The purpose of this study was to investigate the role of Ets-1 in the growth and differentiation of GISTs. METHODS: Twenty-eight GISTs, nine leiomyomas and six schwannomas were examined by immunohistochemical staining method for Ets-1 in this study. Specimens were selected from surgical pathology archival tissues at Nagasaki University Hospital. RESULTS: Ets-1 protein was expressed in the cytoplasm of cells in all of these tumors. Immunohistochemical staining revealed that 27 GISTs (96.4 %), six leiomyomas (66.7 %), and five schwannomas (83.3 %) were positive for Ets-1. Ets-1 expression was statistically different between GISTs and leiomyomas (P |
| Databáze: | OpenAIRE |
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