5-HTTLPR-rs25531 and Antidepressant Treatment Outcomes in Korean Patients with Major Depression
| Autor: | Doh Kwan Kim, Young Kyung Moon, Shinn-Won Lim, Seonwoo Kim, Su-Yeon Kim, Yoo Jin Jang, Hong Lee |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Oncology
medicine.medical_specialty Genotype Logistic regression 03 medical and health sciences 0302 clinical medicine Internal medicine Republic of Korea medicine Humans Pharmacology (medical) Allele frequency Alleles Serotonin Plasma Membrane Transport Proteins Depressive Disorder Major business.industry Depression General Medicine Odds ratio medicine.disease Confidence interval Antidepressive Agents 030227 psychiatry Psychiatry and Mental health Treatment Outcome 5-HTTLPR Major depressive disorder Antidepressant business 030217 neurology & neurosurgery |
| Zdroj: | Pharmacopsychiatry. 54(6) |
| ISSN: | 1439-0795 |
| Popis: | Introduction Despite the ethnic differences in 5-HTTLPR (S allele relates to better antidepressant response in Korean and Japanese people, while L allele with better response in Caucasians), it is unclear whether 5-HTTLPR and its high expression locus rs25531 are interactively associated with antidepressant treatment outcome. We investigated the individual and interaction effects of these polymorphisms on antidepressant treatment outcomes in the Korean population. Methods A total of 464 Korean subjects with major depressive disorder completed 6 weeks of antidepressant monotherapy. Venous blood was extracted for genotyping 5-HTTLPR and rs25531 by polymerase chain reaction and DNA sequencing. We used logistic regression analyses to verify the main and interaction effects of 5-HTTLPR and rs25531 on response and remission after antidepressant treatment. Results After adjusting for covariates, the SS genotype of 5-HTTLPR was significantly associated with better treatment outcomes (p0.05). Discussion Our findings suggest variations in allelic frequency and functionality of 5-HTTLPR and rs25531 among the different ethnicities. We found a minor advantage of rs25531 in achieving remission. However, there was no interaction effect with 5-HTTLPR. |
| Databáze: | OpenAIRE |
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