Nutritional status and metabolic disorders in HIV-exposed uninfected prepubertal children
| Autor: | Daisy Maria Machado, Regina Célia de Menezes Succi, Cristiane Chiantelli Claudio, Rose Vega Patin, Fernanda Luisa Ceragioli Oliveira, Cecília Zanin Palchetti |
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| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Endocrinology Diabetes and Metabolism Human immunodeficiency virus (HIV) Nutritional Status Physiology HIV Infections Biology medicine.disease_cause Body Mass Index Anthropometric parameters Insulin resistance Metabolic Diseases Surveys and Questionnaires Internal medicine Total cholesterol Prevalence medicine Humans Child Dyslipidemias Lipoprotein cholesterol Nutrition and Dietetics Anthropometry medicine.diagnostic_test Nutritional status medicine.disease C-Reactive Protein Cholesterol Cross-Sectional Studies Endocrinology Body Composition Female Insulin Resistance Lipid profile Dyslipidemia |
| Zdroj: | Nutrition. 29:1020-1023 |
| ISSN: | 0899-9007 |
| Popis: | Objective The objective of the study was to assess the nutritional status and metabolic alterations in HIV-exposed uninfected (HIVe) children compared with HIV-unexposed (HIVn) children. Methods A cross-sectional study was carried out with 76 children distributed into two groups: HIVe (n = 31) and HIVn (n = 45). Biochemical data (hematologic test, lipid profile, insulin resistance, hepatic profile, and C-reactive protein) were evaluated. Anthropometric parameters and body composition analyses were performed. Results The groups were similar regarding body mass index-for-age z-scores ( P = 0.297) and height-for-age z-scores ( P = 0.666). HIVe had a higher dyslipidemia prevalence (38.7% versus 11.1%; P = 0.010), altered total cholesterol (TC) values (19.4% versus 2.2%; P = 0.016) higher LDL-C mean levels (97.8 mg/dl versus 86 mg/dl; P = 0.028), borderline low-density lipoprotein cholesterol (LDL-C) (40% versus 14%; P = 0.011) and TC (41.9% versus 20%; P = 0.038) compared with HIVn. Conclusion Despite the similar nutritional status between groups, our data clearly demonstrated a higher prevalence of dyslipidemia, altered TC, higher LDL-C levels and also LDL-C and TC borderline values in HIVe children. |
| Databáze: | OpenAIRE |
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