The sperm stress test: a novel test that predicts pregnancy in assisted reproductive technologies
| Autor: | C B Barrett, Irwin E. Thompson, J F Mortola, D Minaretzis, Juan G. Alvarez |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Semen Reproductive technology Andrology Reproductive Techniques Predictive Value of Tests Pregnancy Stress Physiological medicine Humans Prospective Studies Gamete intrafallopian transfer reproductive and urinary physiology Sperm motility Gynecology In vitro fertilisation urogenital system business.industry Obstetrics and Gynecology medicine.disease Sperm Pregnancy rate Logistic Models Reproductive Medicine Sperm Motility Female business |
| Zdroj: | Fertility and Sterility. 65:400-405 |
| ISSN: | 0015-0282 |
| DOI: | 10.1016/s0015-0282(16)58107-2 |
| Popis: | To develop a reliable sperm test that would predict pregnancy rate in assisted reproductive technologies.Blind prospective cohort study.Tertiary-care, university hospital-affiliated IVF program.One hundred nineteen sperm samples were obtained from 110 males from couples undergoing IVF or GIFT (ART). Sperm samples were washed by Percoll, incubated at 24 degrees C for 4 hours, and an aliquot of the same sperm suspension was used for ART incubated at 40 degrees C for 4 hours (stress test). Stress test scores are expressed as the ratio of final to initial motility.Of 119 ART cycles, 24 resulted in pregnancy. Of 24 pregnancies, 23 occurred in cycles that used sperm samples with stress test scoresor = 0.75 and only one with a stress test score0.75. The negative predictive value of the test, defined as the absence of pregnancy with scores0.75, was 98% and the positive predictive value, defined as the occurrence of pregnancy with scoresor = 0.75, was 36%. Logistic regression analysis indicated that the stress test score alone was correlated significantly with pregnancy after ART.These results indicate that stress test scores0.75 are predictive of poor pregnancy outcome in ART. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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