| Autor: |
Paulo Gil Alabarse, Liang‐Yu Chen, Patricia Oliveira, Huaping Qin, Ru Liu‐Bryan |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Arthritisrheumatology (Hoboken, N.J.). |
| ISSN: |
2326-5205 |
| Popis: |
To determine the role of CD38, which can function as an enzyme to degrade nicotinamide adenosine dinucleotide (NADHuman knee cartilage from normal and OA donors were examined for CD38 expression. Approaches of "gain-of-function" through overexpression of CD38 via transient transfection and of "loss-of-function" through pharmacologic inhibition of CD38 were used to assess the impact of CD38 on intracellular levels of NADCD38 expression was upregulated in human knee OA cartilage and in chondrocytes stimulated with proinflammatory cytokine IL-1β. Overexpression of CD38 in chondrocytes resulted in reduced cellular NADCD38 deficiency exerts OA disease modifying effects. Inhibition of CD38 has a potential to be a novel therapeutic approach for OA treatment. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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