Scrub typhus as a rare cause of acute pyelonephritis: case report
| Autor: | Nishma Pokharel, Tulsi Ram Bhattarai, Suraj Bhattarai, Sujan Chandra Poudel |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Fever 030106 microbiology Case Report Scrub typhus Asymptomatic Communicable Diseases Emerging lcsh:Infectious and parasitic diseases Dengue fever 03 medical and health sciences 0302 clinical medicine Nepal Internal medicine medicine Humans lcsh:RC109-216 030212 general & internal medicine Pneumonitis Acute pyelonephritis Urinary tract infection Pyelonephritis business.industry Ceftriaxone Acute kidney injury Meropenem Middle Aged medicine.disease bacterial infections and mycoses Anti-Bacterial Agents Infectious Diseases Rickettsiosis Scrub Typhus Doxycycline medicine.symptom Teicoplanin business Meningitis Encephalitis |
| Zdroj: | BMC Infectious Diseases BMC Infectious Diseases, Vol 20, Iss 1, Pp 1-5 (2020) |
| ISSN: | 1471-2334 |
| Popis: | Background Scrub typhus can present with atypical signs and symptoms such as those of acute kidney injury, gastroenteritis, pneumonitis, and acute respiratory distress syndrome. Meningitis, encephalitis, and hepatic dysfunction have also been reported, particularly in severe cases with multisystem involvement. Scrub typhus has never been reported in the literature to cause urinary tract infections (UTIs) which includes cystitis and pyelonephritis. Case presentation A 45-year old male presenting to the outpatient unit with fever, right flank pain, and burning micturition for three days was initially treated for UTI. However, he returned to the hospital on the fourth day of illness with persistent symptoms. He was hospitalized, with intravenous (IV) ceftriaxone. Computerized tomography scan of his abdomen-pelvis showed features of acute pyelonephritis, so his antibiotics were upgraded to meropenem and teicoplanin. Despite this, the patient’s condition deteriorated. Laboratory investigations showed multisystem involvement: decreasing platelets, raised creatinine, and deranged liver panel. As Kathmandu was hit by dengue epidemic during the patient’s hospitalization, on the seventh day of his illness, blood samples were sent for tropical fever investigation. All tests came out negative except for scrub typhus—IgM antibodies positive on rapid diagnostic test. The patient’s symptoms subsided after 48 h of starting doxycycline and he became fully asymptomatic four days later. Fever did not recur even after discontinuing other IV antibiotics, favoring scrub typhus disease rather than systemic bacterial sepsis. Conclusions Scrub typhus is an emerging infectious disease of Nepal. Therefore, every unexplained fever cases (irrespective of clinical presentation) should be evaluated for potential Rickettsiosis. Moreover, for cases with acute pyelonephritis, atypical causative agents should be investigated, for example scrub typhus in this case. |
| Databáze: | OpenAIRE |
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