Association of Hepatitis C Virus Infection With CD4/CD8 Ratio in HIV-Positive Women
| Autor: | Roksana Karim, Howard D. Strickler, Michael Plankey, Mark H. Kuniholm, Michael Augenbraun, Audrey L. French, Kathryn Anastos, Thomas R OʼBrien, Christopher B. Pierce, Ludmila Prokunina-Olsson, Monika Sarkar |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
hepatitis C virus
Adult 0301 basic medicine Hepatitis C virus CD4-CD8 Ratio HIV Infections Inflammation Systemic inflammation medicine.disease_cause immune activation 03 medical and health sciences 0302 clinical medicine Antiretroviral Therapy Highly Active medicine Humans Pharmacology (medical) Prospective Studies 030212 general & internal medicine CD4/CD8 Coinfection business.industry Interleukins HIV virus diseases Hepatitis C Clinical Science Hepatitis C Chronic Viral Load Flow Cytometry medicine.disease Virology CD4 Lymphocyte Count 3. Good health 030104 developmental biology Infectious Diseases inflammation HCV Immunology ComputingMethodologies_DOCUMENTANDTEXTPROCESSING Female medicine.symptom business Viral load Biomarkers CD8 |
| Zdroj: | Journal of Acquired Immune Deficiency Syndromes (1999) |
| ISSN: | 1525-4135 |
| DOI: | 10.1097/qai.0000000000000928 |
| Popis: | Supplemental Digital Content is Available in the Text. Background: Recent studies reported that the CD4/CD8 T-cell ratio is inversely associated with biomarkers traditionally used to measure immune activation and systemic inflammation in highly active antiretroviral therapy–treated HIV-infected (HIV+) patients. The relation of hepatitis C virus (HCV) coinfection with the CD4/CD8 ratio in HIV+ patients is unknown. Methods: We examined 50,201 CD4/CD8 ratios measured over 20 years in 3 groups of HIV+ women enrolled in the Women's Interagency HIV Study: HCV antibody negative (n = 1734), cleared HCV (n = 231), and chronic HCV (n = 751) in multivariate models. IFNL4-ΔG genotype and HCV viral load were also considered. Results: Compared with HCV antibody negative status, chronic HCV infection was associated with lower CD4/CD8 ratios when HIV viral load was suppressed to the lower limit of quantification (β = −0.08; P = 0.002). Cleared HCV (β = −0.10; P = 0.0009), but not IFNL4-ΔG genotype or HCV viral load, was also associated with lower CD4/CD8 ratios when HIV viral load was suppressed to the lower limit of quantification. Conclusions: The association of HCV coinfection with CD4/CD8 ratio is consistent with previously observed associations of HCV coinfection with biomarkers traditionally used to measure immune activation and systemic inflammation in HIV+ patients. These data provide additional support for the use of CD4/CD8 ratio for routine monitoring of immune activation and inflammation in HIV+ patients, including those with HIV/HCV coinfection; however, the unexpected association between cleared HCV and lower CD4/CD8 ratio requires additional study. |
| Databáze: | OpenAIRE |
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