SARS-CoV-2 does not replicate in embryonated hen’s eggs or in MDCK cell lines

Autor:	Ian G. Barr, Julian Druce, Paul G. Whitney, Cleve Rynehart
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	0301 basic medicine Virus Cultivation Epidemiology Influenza vaccine viruses Eggs Pneumonia Viral Biology medicine.disease_cause Severe Acute Respiratory Syndrome Virus Replication Virus Cell Line Madin Darby Canine Kidney Cells 03 medical and health sciences severe acute respiratory syndrome – SARS influenza virus biosafety vaccines and immunisation laboratory Betacoronavirus 0302 clinical medicine Dogs Virology Influenza Human medicine Animals Humans 030212 general & internal medicine skin and connective tissue diseases Influenza SARS-CoV-2 vaccine respiratory air-borne infections viral infections influenza Pandemics Coronavirus SARS-CoV-2 fungi Public Health Environmental and Occupational Health Embryonated virus diseases COVID-19 medicine.disease body regions 030104 developmental biology Viral replication Cell culture Influenza Vaccines Receptors Virus Severe acute respiratory syndrome Coronavirus Infections Chickens Rapid Communication
Zdroj:	Eurosurveillance
ISSN:	1560-7917 1025-496X
Popis:	The advent of COVID-19, has posed a risk that human respiratory samples containing human influenza viruses may also contain SARS-CoV-2. This potential risk may lead to SARS-CoV-2 contaminating conventional influenza vaccine production platforms as respiratory samples are used to directly inoculate embryonated hen’s eggs and continuous cell lines that are used to isolate and produce influenza vaccines. We investigated the ability of these substrates to propagate SARS-CoV-2 and found that neither could support SARS-CoV-2 replication.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82a4fc7b9747f7fd0139b0583efd09e9 http://europepmc.org/articles/PMC7331139 Zobrazit plný text záznamu