Mannose-binding lectin gene polymorphism and its impact on human immunodeficiency virus 1 infection
| Autor: | Marluísa de Oliveira Guimarães Ishak, Ricardo Ishak, Anna Elizabeth Martins Alves, Lia Lobato Batista de Souza, Vânia Nakauth Azevedo, Luiz Fernando Almeida Machado, Marcos Rogério Menezes-Costa, Antonio Carlos Rosário Vallinoto |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Genotype
Immunology Human immunodeficiency virus (HIV) Serum protein HIV Infections chemical and pharmacologic phenomena medicine.disease_cause Mannose-Binding Lectin Plasma viral load Gene Frequency medicine Humans Viremia Allele Molecular Biology Alleles Volume concentration Mannan-binding lectin Polymorphism Genetic Base Sequence biology Lectin DNA bacterial infections and mycoses CD4 Lymphocyte Count Case-Control Studies HIV-1 biology.protein Gene polymorphism Brazil |
| Zdroj: | Molecular Immunology. 43:1358-1362 |
| ISSN: | 0161-5890 |
| DOI: | 10.1016/j.molimm.2005.09.001 |
| Popis: | Mannose-binding lectin (MBL) is a serum protein whose low concentration is associated with the occurrence of allele variants named MBL*B, MBL*C and MBL*D. The present study investigated the association between MBL gene polymorphism and the susceptibility to HIV-1 infection. The study of 145 HIV-1-infected subjects and 99 healthy controls showed the presence of alleles MBL*A, MBL*B and MBL*D, whose frequencies were 69%, 22% and 09% among patients and 71%, 13% and 16% among healthy controls, respectively. The presence of the variant MBL*B was associated with higher plasma viral load levels, suggesting the importance of the MBL gene polymorphism in the clinical evolution of HIV-1-infected patients. |
| Databáze: | OpenAIRE |
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