Expression of aldehyde dehydrogenase 1 (ALDH1) in endometrioid adenocarcinoma and its clinical implications
| Autor: | Yi Wang, Tadashi Kimura, Shinya Matsuzaki, Suhana Mamat, Reina Umehara, Eiichi Morii, Yutaka Ueda, Nur Rahadiani, Tian Tian, Jun-ichiro Ikeda, Takayuki Enomoto, Katsuyuki Aozasa |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Cancer Research Poor prognosis Pathology medicine.medical_specialty Lymphovascular invasion Aldehyde dehydrogenase Antineoplastic Agents Tumor cells Aldehyde Dehydrogenase 1 Family Immunoenzyme Techniques Young Adult Cell Movement Biomarkers Tumor Cell Adhesion Tumor Cells Cultured Overall survival medicine Humans Endometrioid adenocarcinoma Neoplasm Invasiveness Progenitor cell Aged Cell Proliferation Neoplasm Staging biology T category Retinal Dehydrogenase General Medicine Middle Aged Prognosis Endometrial Neoplasms Isoenzymes Survival Rate Oncology Drug Resistance Neoplasm Disease Progression Cancer research biology.protein Female Cisplatin Neoplasm Recurrence Local Carcinoma Endometrioid |
| Zdroj: | Cancer Science. 102:903-908 |
| ISSN: | 1347-9032 |
| DOI: | 10.1111/j.1349-7006.2011.01864.x |
| Popis: | Aldehyde dehydrogenase 1 (ALDH1) is expressed in stem/progenitor cells, including cancer-initiating cells (CIC) of various organs. In the present study, ALDH1 expression was immunohistochemically examined in uterine endometrioid adenocarcinoma. The ALDH1 was expressed in a small portion of tumor cells, and these ALDH1-expressing cells were less mature than ALDH1-non-expressing cells. The ALDH1-expressing (ALDH1-hi) cells were more tumorigenic, resistant to anti-cancer agents and more invasive than ALDH1-lo cells. Culture of the sorted ALDH1-hi cells yielded both ALDH1-hi and ALDH1-lo cells, whereas ALDH1-lo cells yielded ALDH-lo cells alone. Clinically, a high-level of ALDH1 expression in tumor cells was correlated with T category, lymphatic invasion, recurrence and prognosis of patients. Patients with high ALDH1 expression showed poorer prognoses than those with low expression (P = 0.015 for disease-free survival [DFS] and P = 0.010 for overall survival [OS]), and high ALDH1 expression was an independent factor for poor prognosis. Aldehyde dehydrogenase 1 is a candidate for CIC marker for uterine endometrioid adenocarcinoma. |
| Databáze: | OpenAIRE |
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