Data of physiological measurements and quality of life in subjects with mild to moderate COPD compared to asymptomatic current smokers, former smokers and never-smokers
| Autor: | Gregory Vuillaume, Elena Pierri, Michael J. Peck, Loyse Felber-Medlin, Manuel C. Peitsch, Julia Hoeng, Karsta Luettich, Patrice Leroy, Nveed Chaudhary |
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| Rok vydání: | 2017 |
| Předmět: |
Spirometry
medicine.medical_specialty gas transfer Physiology Disease Data Note Asymptomatic General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Quality of life Internal medicine medicine COPD 030212 general & internal medicine General Pharmacology Toxicology and Pharmaceutics impulse oscillometry COPD & Allied Disorders lung sound analysis General Immunology and Microbiology medicine.diagnostic_test business.industry lung function General Medicine Articles Omics medicine.disease Obstructive lung disease respiratory tract diseases 030228 respiratory system Biomarker (medicine) biomarker medicine.symptom business |
| Zdroj: | F1000Research |
| ISSN: | 2046-1402 0178-0298 |
| Popis: | Chronic obstructive pulmonary disease (COPD) is a common inflammatory airway disease predominantly associated with cigarette smoking, and its incidence is increasing worldwide. According to the Global Initiative for Obstructive Lung Disease (GOLD) guidelines, spirometry is used to diagnose the disease. However, owing to its complexity, spirometry alone may not account for the multitude of COPD phenotypes or the early, asymptomatic lung damage seen in younger smokers. In addition, suitable biomarkers enabling early diagnosis, guiding treatment and estimating prognosis are still scarce, although large scale ‘omics analyses have added to the spectrum of potential biomarkers that could be used for these purposes. The aim of the current study was to comprehensively profile patients with mild-to-moderate COPD and compare the profiles to i) a group of currently smoking asymptomatic subjects, ii) a group of healthy former smokers, and iii) a group of healthy subjects that had never smoked. The assessment was conducted at the molecular level using proteomics, transcriptomics, and lipidomics and complemented by a series of measurements of traditional and emerging indicators of lung health (ClinicalTrials.gov identifier: NCT01780298). In this data note, we provide a comprehensive description of the study population’s physiological characteristics including full lung function, lung appearance on chest computed tomography, impulse oscillometry, and exercise tolerance and quality of life (QoL) measures. |
| Databáze: | OpenAIRE |
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