The Levels of Cortisol and Oxidative Stress and DNA Damage in Child and Adolescent Victims of Sexual Abuse with or without Post-Traumatic Stress Disorder
| Autor: | Tuğba Yüksel, Şeref Şimşek, Cem Uysal, Hüseyin Aktaş, İbrahim Kaplan |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty DNA damage Physiology medicine.disease_cause Trauma Cortisol Child and adolescent Superoxide dismutase 03 medical and health sciences 0302 clinical medicine mental disorders Medicine Psychiatry Biological Psychiatry chemistry.chemical_classification biology business.industry Glutathione peroxidase Sexual abuse Traumatic stress PTSD Psychiatry and Mental health 030104 developmental biology chemistry Oxidative stress biology.protein Original Article Psychiatric interview business 030217 neurology & neurosurgery |
| Zdroj: | Psychiatry Investigation |
| ISSN: | 1976-3026 1738-3684 |
| Popis: | OBJECTIVE The aim of this study was to investigate whether cortisol and oxidative stress levels and DNA damage differ between individuals who developed PTSD or not following a sexual trauma. METHODS The study included 61 children aged between 5 and 17 years who sustained sexual abuse (M/F: 18/43). The patients were divided into two groups: patients with PTSD and patients without PTSD based, based on the results of a structured psychiatric interview (K-SADS-PL and CAPS-CA). Cortisol, glutathione peroxidase (GPx), superoxide dismutase (SOD), coenzyme Q, 8-Hydroxy-2-Deoxyguanosine (8-OHdG) were all evaluated by the ELISA method. RESULTS Our evaluation revealed a diagnosis of PTSD in 51% (n=31) of victims. There was no significant difference between the groups with or without PTSD in terms of cortisol, GPx, SOD, coenzyme Q, and 8-OHdG levels. There was no correlation between CAPS scores and GPx, SOD, coenzyme Q, and 8-OHdG levels between patients with or without PTSD. In patients with PTSD, both cortisol and 8-OHdG levels decreased with increasing time after trauma, and there was no significant correlation with cortisol and 8-OHdG levels in patients without PTSD. CONCLUSION Although the present study did not find any difference between the groups in terms of 8-OHdG concentrations, the decreases in both cortisol and 8-OHdG levels with increasing time after trauma is considered to indicate a relationship between cortisol and DNA damage. |
| Databáze: | OpenAIRE |
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