Trials with the Haemonchus vaccine, Barbervax®, in ewes and lambs in a tropical environment: Nutrient supplementation improves protection in periparturient ewes

Autor: André M. Castilhos, George F.J. Newlands, César Cristiano Bassetto, W. D. Smith, Edson Ramos de Siqueira, Simone Fernandes, Fabiana Alves de Almeida, Alessandro Francisco Talamini do Amarante
Přispěvatelé: Universidade Estadual Paulista (Unesp), Moredun Research Institute
Rok vydání: 2018
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Zdroj: Scopus
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
ISSN: 0304-4017
DOI: 10.1016/j.vetpar.2018.11.006
Popis: Made available in DSpace on 2019-10-06T16:05:39Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-12-15 Haemonchus contortus is an economic problem in sheep farms worldwide, mainly in the tropics and subtropics. A vaccine against haemonchosis, called Barbervax®, was evaluated in ewes under two nutritional status, naturally infected with gastrointestinal nematodes. Ewes were divided into four groups: Supplemented Diet – Vaccine; Supplemented Diet – No vaccine; Basal Diet – Vaccine and Basal Diet – No vaccine. Their lambs were divided in Vaccinated and No vaccine. Ewes were immunised six times starting about 1 month of pregnancy with the first three doses at 3 week intervals and the last three shots at 4 week intervals. Supplemented ewes had higher body weight, body score and packed cell volume compared with those fed a basal diet. Both groups of vaccinated ewes showed a similar response in circulating anti-vaccine antibodies but the vaccine had no discernible effect on either body weight, body score and packed cell volume. There was a marked group difference in the number of ewes that received precautionary treatments with anthelmintic. All 14 Basal Diet – No vaccine ewes required treatment. In contrast only 7 ewes, in the Supplemented Diet – Vaccine group required anthelmintic treatment. In the Basal Diet – Vaccine and in the Supplemented Diet – No Vaccine groups, 12 and 13 ewes needed anthelmintic treatment, respectively. Vaccinated lambs showed much higher antibody titres resulting in 80% less Haemonchus spp. egg counts comparing with no vaccine lambs. Taken together these results clearly suggest that in pregnant and lactating ewes a combined protective effect between vaccination and improved nutrition resulted in fewer precautionary anthelmintic treatments. Thus, it was possible to achieve a more sustainable level of control of the haemonchosis, less dependent on anthelmintic drugs. UNESP - Universidade Estadual Paulista Departamento de Parasitologia Instituto de Biociências Moredun Research Institute, Pentlands Science Park, Bush Loan, Penicuik UNESP - Universidade Estadual Paulista Departamento de Produção Animal Faculdade de Medicina Veterinária e Zootecnia Fazenda Experimental Lageado, Botucatu UNESP - Universidade Estadual Paulista Departamento de Parasitologia Instituto de Biociências UNESP - Universidade Estadual Paulista Departamento de Produção Animal Faculdade de Medicina Veterinária e Zootecnia Fazenda Experimental Lageado, Botucatu
Databáze: OpenAIRE
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