Polyprenylated acylphloroglucinols as deubiquitinating protease USP7 inhibitors from Hypericum hookerianum
| Autor: | Qiang-Qiang Fang, Ling-Zhi Wu, Ya-Nan Liu, Chang-Heng Tan, Kun Jiang, Shi-Jin Qu, Qi-Qi Wang, Xiao-Dong Wang |
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| Rok vydání: | 2020 |
| Předmět: |
Pharmacology
Plant Components China Protease Molecular Structure 010405 organic chemistry Chemistry Stereochemistry medicine.medical_treatment Hypericum hookerianum Phytochemicals General Medicine Phloroglucinol Plant Components Aerial 01 natural sciences 0104 chemical sciences Ubiquitin-Specific Peptidase 7 010404 medicinal & biomolecular chemistry Drug Discovery medicine Protease Inhibitors Hypericum |
| Zdroj: | Fitoterapia. 146 |
| ISSN: | 1873-6971 |
| Popis: | Hookerianones A – E (1–5), five new polyprenylated acylphloroglucinols (PPAPs), along with six known ones, were isolated from the aerial parts of Hypericum hookerianum. Their structures were elucidated by analyses of MS, NMR, chiroptical properties, biogenetic pathway, and/or single crystal X-ray diffraction. A ubiquitin-rhodamine 110 assay showed that furohyperforin and hypercalin C, two representative PPAPs in this plant, inhibited more than 90% USP7 at the concentration of 10 μM. |
| Databáze: | OpenAIRE |
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