Can ultrasensitive thyroglobulin immunoassays avoid the need for ultrasound in thyroid cancer follow-up?

Autor: Jacopo Manso, Gianmaria Pennelli, Francesca Galuppini, Diego Faggian, Loris Bertazza, Caterina Mian, Maurizio Iacobone, Susi Barollo, Antonio De Rosa, Mario Plebani, Simona Censi, Isabella Merante-Boschin, Federica Vianello
Rok vydání: 2021
Předmět:
Zdroj: Endocrine. 75:837-845
ISSN: 1559-0100
1355-008X
Popis: Differentiated thyroid cancer (DTC) is the most common endocrine neoplasm, with a rising incidence and a long life expectancy. It has recently been suggested that patients with low- and intermediate-risk DTC with a good response to treatment at one year could be followed up using only highly sensitive immunoassays for thyroglobulin (Tg). The aim of this study was to examine the serum Tg levels in a series of DTC patients with histologically proven persistent or recurrent diseases. The study involved 50 consecutive patients being routinely followed up at our center, whose clinical, histological, and biochemical data were retrospectively collected. The false-negative rate of ultrasensitive serum Tg assay was 14.3% (5/35) overall, and limited to anti-thyroglobulin autoantibodies (TgAb)-negative patients. Among them, only one patient had an excellent response to treatment at one-year follow-up and was diagnosed with a 4 mm recurrence, after more than seven years of periodic ultrasounds. The size of the neck lesion documented in the histological report was slightly larger in patients with detectable as opposed to negative Tg values (P
Databáze: OpenAIRE
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