Detection of local recurrence of prostate cancer after radical prostatectomy: Is there a role for early 18F-FCH PET/CT?
| Autor: | Paolo Abbatiello, Mario Tavolozza, Agostino Chiaravalloti, Daniele Di Biagio, Orazio Schillaci |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
PET-CT
medicine.medical_specialty medicine.diagnostic_test business.industry Prostatectomy medicine.medical_treatment Retrospective cohort study General Medicine medicine.disease Radiation therapy Prostate cancer Prostate-specific antigen 18F-FCH PET/CT Local recurrence Early acquisition Prostate cancer PSA Settore MED/36 - Diagnostica per Immagini e Radioterapia Positron emission tomography parasitic diseases medicine Hormonal therapy Radiology Nuclear Medicine and imaging Radiology business Nuclear medicine |
| Popis: | To investigate the diagnostic performance of early acquisition compared to late imaging for the detection of local recurrence of prostate cancer by means of 18F-FCH PET/CT. 99 patients with radical prostatectomy (mean PSA 3.9 ± 5.03) were subjected to early dynamic PET/CT acquisition of the pelvis and a whole body PET/CT in the same exam session. None of the patients examined was subjected to radiotherapy for local or distant recurrence. All the subjects were taken off hormonal therapy. 58 subjects did not show local recurrence in both early and late acquisition, 22 were positive in both modalities, 10 showed a positive early and a negative late acquisition while 9 showed a negative early and a positive late acquisition (Cohen’s k = 0.558). When the results of imaging modalities were considered separately, sensitivity, specificity, positive predictive value and negative predictive value resulted: 78.9, 96.7, 93.8 and 88.1 % for early acquisition and 73.7, 95.1, 90.3 and 85.3 % for late acquisition, respectively. When the results of early and late acquisition were considered together, results were 97.4, 93.4, 90.2 and 98.3 %, respectively. The combination of early acquisition with late acquisition lead to an increase of the diagnostic accuracy of 18F-FCH PET/CT for the diagnosis of local recurrence in prostate cancer. |
| Databáze: | OpenAIRE |
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