Humoral Intestinal Immunity in Systemic Lupus Erythematosus
| Autor: | José Ângelo Papi, Albanita Viana de Oliveira, Heitor Siffert Pereira de Souza, Carlos Augusto Mello, Rosa Cuckier, Ana Teresa Pugas Carvalho, Celeste C. Elia, Kalil Madi |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Adult
Pathology medicine.medical_specialty Systemic disease Adolescent Fluorescent Antibody Technique Basement Membrane Immune system Immunopathology Humans Lupus Erythematosus Systemic Medicine Lupus band test Intestinal Mucosa skin and connective tissue diseases Lamina propria Lupus erythematosus biology business.industry Gastroenterology Middle Aged medicine.disease Immunoglobulin A Cross-Sectional Studies Jejunum medicine.anatomical_structure Immunoglobulin M Immunoglobulin G Antibody Formation Humoral immunity Immunology biology.protein Female Antibody business |
| Zdroj: | Journal of Clinical Gastroenterology. 30:52-55 |
| ISSN: | 0192-0790 |
| DOI: | 10.1097/00004836-200001000-00009 |
| Popis: | Forty-five patients with systemic lupus erythematosus (SLE) underwent a cross-sectional study to evaluate intestinal secretory immunity. Peroral jejunal biopsy with histologic and immunohistochemical assessment of the mucosa were carried out in the patients and in 12 healthy volunteers. It was observed that an altered pattern of immunoglobulin-bearing plasma cells distributed in the lamina propria and complementary components were invariably present, mainly in the patients with active disease. The basement membrane of the intestinal crypt epithelium exhibited immunoglobulin and complementary deposits, similar to the lupus band test. None of the immunologic findings correlated with the medical treatment and with the peripheral blood analysis. The local changes in humoral immunity in patients with SLE did not correlate with gastrointestinal symptoms and may reflect the systemic effects of the disease. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|