Clinical Factors, But Not C-Reactive Protein, Predict Progression of Calcific Aortic-Valve Disease
| Autor: | Gian M. Novaro, Catherine M Otto, Ronnier J. Aviles, John S. Gottdiener, Brian P. Griffin, Mary Cushman, Bruce M. Psaty, Ronit Katz |
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| Rok vydání: | 2007 |
| Předmět: |
medicine.medical_specialty
education.field_of_study biology medicine.diagnostic_test business.industry C-reactive protein Population Odds ratio Doppler echocardiography medicine.disease Stenosis Internal medicine Circulatory system Cohort cardiovascular system biology.protein medicine Cardiology Cardiology and Cardiovascular Medicine business education Subclinical infection |
| Zdroj: | Journal of the American College of Cardiology. 50:1992-1998 |
| ISSN: | 0735-1097 |
| Popis: | Objectives The purpose of this study was to examine the relationship between C-reactive protein (CRP) and calcific aortic valve disease in a large, randomly selected, population-based cohort. Background The pathobiology of calcific aortic stenosis involves an active inflammatory, atheromatous, osteogenic process. Elevations in CRP, a measure of systemic inflammation, have been associated with aortic stenosis. Methods Two-dimensional and Doppler echocardiography and CRP measurement were performed at baseline in 5,621 participants in the Cardiovascular Health Study. Multivariable analysis was used to identify CRP as a predictor of baseline and incident aortic stenosis. Results At a mean echocardiographic follow-up of 5 years, 9% of subjects with aortic sclerosis progressed to some degree of aortic stenosis. Increasing age (odds ratio [OR] 1.13, 95% confidence interval [CI] 1.09 to 1.16; p Conclusions In this large population-based cohort, approximately 9% of subjects with aortic sclerosis progressed to aortic stenosis over a 5-year follow-up period. There was no association between CRP levels and the presence of calcific aortic-valve disease or incident aortic stenosis. C-reactive protein appears to be a poor predictor of subclinical calcific aortic-valve disease. |
| Databáze: | OpenAIRE |
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