The incidences of other primary cancers in patients with mycosis fungoides and Sézary syndrome
| Autor: | Maciej Jaśkiewicz, Izabela Błażewicz, Małgorzata Sokołowska-Wojdyło, Marta Stawczyk-Macieja, Roman Nowicki, Berenika Olszewska |
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| Rok vydání: | 2021 |
| Předmět: |
Original Paper
medicine.medical_specialty Mycosis fungoides mycosis fungoides business.industry Cancer Dermatology lymphomas medicine.disease RC31-1245 Cutaneous lymphoma Lymphoma Breast cancer RL1-803 Sézary syndrome hemic and lymphatic diseases medicine cancer Immunology and Allergy Basal cell carcinoma Lymphomatoid papulosis Lung cancer business Internal medicine |
| Zdroj: | Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii Advances in Dermatology and Allergology, Vol 38, Iss 2, Pp 289-294 (2021) |
| ISSN: | 1642-395X |
| DOI: | 10.5114/ada.2021.106205 |
| Popis: | Introduction Cutaneous T-cell lymphomas (CTCLs) are a diverse group of non-Hodgkin's lymphomas with malignant T lymphocytes infiltrating the skin. Mycosis fungoides (MF) and Sezary syndrome (SS) belong to the group of CTCLs, among others. In previous studies it was suggested that primary cancers more often occur in patients with cutaneous lymphoma. Aim To analyse the incidence of other malignancies in CTCL patients. Material and methods The evaluation of the coexistence of primary malignant neoplasms in CTCL patients was conducted by analysis of the patients' database, with diagnosis of mycosis fungoides and Sezary syndrome, treated in the Dermatological Department of the Medical University of Gdansk between 2010 and 2018. Results Among CTCL patients, 177 were diagnosed with MF/SS (stage MFIA 37.61%, MFIB 30.77%, MFIIA 0.85%, MFIIB 11.11%, MFIII 8.55% MFIV 4.27%; SS 6.84%). The group was characterized by a male-to-female ratio of 1.21 : 1. 16.94% of MF/SS patients had one co-existing cancer, while 1.13% of patients had 2 co-existing cancers; the most common were basal cell carcinoma, lymphomatoid papulosis, lung cancer, and B-cell lymphoma. The obtained data highlight that MF/SS is associated with increased risk of cancer. Conclusions Our study suggests that special attention should be paid to careful examination of CTCL patients - what force to perform solid clinical examination, the X-ray chest examination, abdomen USG, mammography, and others, even in early stages of MF/SS. Clinicians should be aware of the coexistence of other neoplasms such as lung, skin, and breast cancer. |
| Databáze: | OpenAIRE |
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