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Objectives: To investigate the relationship between ALT and HCV titer detected by PCR. Since HCV infection is a widespread threat worldwide, this relationship would be very helpful in making clinical decisions in the treatment of this disease. Place and duration: In the Medicine department of Holy Family Hospital Rawalpindi for one-year duration from February 2019 to February 2020. Subjects: HCV patients with positive RNA PCR analysis. Study design: Observational descriptive study. Methods: 100 patients were included in the study. Patients with known HCV disease and HCV RNA positive PCR were included in the study. Patients with HCV RNA negative PCR were not included in this study. Data were entered and analyzed using SPSS 17.0. This was done from known patients with HCV positive at FMH Hospital in Lahore. The blood sample was taken by sterile technique. The sample was centrifuged and fresh serum was obtained, which was then transferred into aliquots and stored at -200 ° C until series. Results: Of the 100 samples, PCR results with high viral load did not show an increase in blood ALT, and those with low viral load did not necessarily show a decrease in blood ALT (p Conclusion: This study showed that there is an insignificant relationship between viral load and HCV alanine transaminase PCR. Keywords: PCR, ALT, Viral load, HCV |
