Desloratadine Exposure and Incidence of Seizure : A Nordic Post-authorization Safety Study Using a New-User Cohort Study Design, 2001–2015

Autor: Martha Emneus, Daniel Mines, Kristian Aasbjerg, Annette Kjær Ersbøll, Joanne E. Brady, Christian Vestergaard, Alfred Peter Born, Kaushik Sengupta, Eline Aas, Kristian Bolin, Thora Majlund Kjærulff, Eero Pukkala, Gunnar Gislason, Dena R. Ramey
Přispěvatelé: Tampere University, Health Sciences
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Ersbøll, A K, Sengupta, K, Pukkala, E, Bolin, K, Aas, E, Emneus, M, Ramey, D R, Brady, J E, Mines, D, Aasbjerg, K, Vestergaard, C, Gislason, G, Born, A P & Kjærulff, T M 2021, ' Desloratadine Exposure and Incidence of Seizure : A Nordic Post-authorization Safety Study Using a New-User Cohort Study Design, 2001-2015 ', Drug Safety, vol. 44, no. 11, pp. 1231-1242 . https://doi.org/10.1007/s40264-021-01106-7
Ersbøll, A K, Sengupta, K, Pukkala, E, Bolin, K, Aas, E, Emneus, M, Ramey, D R, Brady, J E, Mines, D, Aasbjerg, K, Vestergaard, C, Gislason, G, Born, A P & Kjærulff, T M 2021, ' Desloratadine Exposure and Incidence of Seizure : A Nordic Post-authorization Safety Study Using a New-User Cohort Study Design, 2001–2015 ', Drug Safety, vol. 44, no. 11, pp. 1231-1242 . https://doi.org/10.1007/s40264-021-01106-7
Ersbøll, A K, Sengupta, K, Pukkala, E, Bolin, K, Aas, E, Emneus, M, Ramey, D R, Brady, J E, Mines, D, Aasbjerg, K, Vestergaard, C, Gislason, G, Born, A P & Kjærulff, T M 2021, ' Desloratadine Exposure and Incidence of Seizure : A Nordic Post-authorization Safety Study Using a New-User Cohort Study Design, 2001-2015 ', Drug Safety, vol. 44, pp. 1231–1242 . https://doi.org/10.1007/s40264-021-01106-7
Drug Safety
DOI: 10.1007/s40264-021-01106-7
Popis: Introduction A small number of adverse events of seizure in patients using desloratadine (DL) have been reported. The European Medicines Agency requested a post-authorization safety study to investigate whether there is an association between DL exposure and seizure. Objective The aim was to study the association between DL exposure and incidence of first seizure. Methods A new-user cohort study of individuals redeeming a first-ever prescription of DL in Denmark, Finland, Norway, and Sweden in 2001–2015 was conducted. DL exposure was defined as days’ supply plus a 4-week grace period. DL unexposed periods were initiated 27 weeks after DL prescription redemption. Poisson regression was used to estimate the adjusted incidence rate and adjusted incidence rate ratio (aIRR) of incident seizure. Results A total of 1,807,347 first-ever DL users were included in the study, with 49.3% male and a mean age of 29.5 years at inclusion; 20.3% were children aged 0–5 years. The adjusted incidence rates of seizure were 21.7 and 31.6 per 100,000 person-years during DL unexposed and exposed periods, respectively. A 46% increased incidence rate of seizure was found during DL exposed periods (aIRR = 1.46, 95% confidence interval [CI] 1.34–1.59). The aIRR ranged from 1.85 (95% CI 1.65–2.08) in children aged 0–5 years to 1.01 in adults aged 20 years or more (95% CI 0.85–1.19). Conclusion This study found an increased incidence rate of seizure during DL exposed periods as compared to unexposed periods among individuals younger than 20 years. No difference in incidence rate of seizure was observed in adults between DL exposed and unexposed. Supplementary Information The online version contains supplementary material available at 10.1007/s40264-021-01106-7.
Databáze: OpenAIRE
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