Prediction Model for Bronchopulmonary Dysplasia in Preterm Newborns
| Autor: | Krzysztof Preis, Iwona Domzalska-Popadiuk, Dagmara Klasa-Mazurkiewicz, Joanna Jassem-Bobowicz, Anton Żawrocki, Sebastian Kwiatkowski, Katarzyna Stefańska |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Pediatrics
medicine.medical_specialty Multivariate analysis behavioral disciplines and activities Article RJ1-570 predictive model Ductus arteriosus mental disorders bronchopulmonary dysplasia respiratory insufficiency medicine preterm newborns gestational age Receiver operating characteristic business.industry non-invasive ventilation Area under the curve Gestational age Retrospective cohort study Odds ratio medicine.disease medicine.anatomical_structure Bronchopulmonary dysplasia Pediatrics Perinatology and Child Health business |
| Zdroj: | Children, Vol 8, Iss 886, p 886 (2021) Children Volume 8 Issue 10 |
| ISSN: | 2227-9067 |
| Popis: | OBJECTIVE: To develop a multifactorial model that allows the prediction of bronchopulmonary dysplasia (BPD) in preterm newborns. MATERIALS AND METHODS: A single-center retrospective study of infants born below 32 + 0 weeks gestational age. We created a receiver operating characteristic curve to assess the multifactorial BPD risk and calculate the BPD risk accuracy using the area under the curve (AUC). BPD risk was categorized using a multifactorial predictive model based on the weight of the evidence. RESULTS: Of the 278 analyzed preterm newborns, 127 (46%) developed BPD. The significant risk factors for BPD in the multivariate analysis were gestational age, number of red blood cell concentrate transfusions, number of surfactant administrations, and hemodynamically significant patent ductus arteriosus. The combination of these factors determined the risk of developing BPD, with an AUC value of 0.932. A multifactorial predictive model based on these factors, weighted by their odds ratios, identified four categories of newborns with mean BPD risks of 9%, 59%, 82%, and 100%. CONCLUSION: A multifactorial model based on easily available clinical factors can predict BPD risk in preterm newborns and inform potential preventive measures. |
| Databáze: | OpenAIRE |
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