Perfluorocarbon NVX-108 increased cerebral oxygen tension after traumatic brain injury in rats
| Autor: | Paula F. Moon-Massat, Saad H. Mullah, Biswajit K. Saha, Peter B. Walker, Anke H. Scultetus, Ashraful Haque, Charles R. Auker, Brittany Hazzard, Richard M. McCarron, Francoise Arnaud, Rania Abutarboush |
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| Rok vydání: | 2016 |
| Předmět: |
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Traumatic brain injury Partial Pressure Blood Pressure 030204 cardiovascular system & hematology Rats Sprague-Dawley 03 medical and health sciences 0302 clinical medicine Heart Rate Brain Injuries Traumatic Heart rate Animals Medicine Hypoxia Molecular Biology Cerebral Cortex Fluorocarbons business.industry General Neuroscience Hypoxia (medical) medicine.disease Rats nervous system diseases Oxygen tension Blood pressure medicine.anatomical_structure Cerebral cortex Anesthesia Neurology (clinical) Analysis of variance Cerebral oxygen medicine.symptom business 030217 neurology & neurosurgery Developmental Biology |
| Zdroj: | Brain Research. 1634:132-139 |
| ISSN: | 0006-8993 |
| DOI: | 10.1016/j.brainres.2016.01.012 |
| Popis: | Background Hypoxia is a critical secondary injury mechanism in traumatic brain injury (TBI), and early intervention to alleviate post-TBI hypoxia may be beneficial. NVX-108, a dodecafluoropentane perfluorocarbon, was screened for its ability to increase brain tissue oxygen tension (PbtO 2 ) when administered soon after TBI. Methods Ketamine-acepromazine anesthetized rats ventilated with 40% oxygen underwent moderate controlled cortical impact (CCI)-TBI at time 0 (T0). Rats received either no treatment (NON, n =8) or 0.5 ml/kg intravenous (IV) NVX-108 (NVX, n =9) at T15 (15 min after TBI) and T75. Results Baseline cortical PbtO 2 was 28±3 mm Hg and CCI-TBI resulted in a 46±6% reduction in PbtO 2 at T15 ( P P =0.013) were found when comparing either absolute or percentage change of PbtO 2 to post-injury (mixed-model ANOVA) suggesting that administration of NVX-108 increased PbtO 2 above injury levels while it remained depressed in the NON group. Specifically in the NVX group, PbtO 2 increased to a peak 143% of T15 ( P =0.02) 60 min after completion of NVX-108 injection (T135). Systemic blood pressure was not different between the groups. Conclusion NVX-108 caused an increase in PbtO 2 following CCI-TBI in rats and should be evaluated further as a possible immediate treatment for TBI. |
| Databáze: | OpenAIRE |
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