Terpenoid and phenolic constituents from the roots of Ilex pubescens
| Autor: | Yuan Zhou, Yi-Yuan Xi, Xiang-Wei Xu, Xu-Dong Zhou |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
China
Platelet Aggregation Monoterpene Phytochemicals Ilex pubescens Ilex Aquifoliaceae Plant Roots 01 natural sciences chemistry.chemical_compound Phenols Drug Discovery Animals Organic chemistry Pharmacology chemistry.chemical_classification Molecular Structure Terpenes 010405 organic chemistry Glycoside General Medicine Terpenoid 0104 chemical sciences 010404 medicinal & biomolecular chemistry Caffeoylquinic acid Aglycone chemistry Rabbits Two-dimensional nuclear magnetic resonance spectroscopy |
| Zdroj: | Fitoterapia. 138:104298 |
| ISSN: | 0367-326X |
| Popis: | Five new metabolites, including two monoterpene glycosides Pubescenosides L–M (1–2) and three phenolic glycosides, Pubescenosides N-P (3–5), along with nineteen known ones, including liganoids, hemiterpenoids and caffeoylquinic acid derivates, were isolated from the roots of Ilex pubescens. Their structures were elucidated from extensive spectroscopic analysis, including 1D and 2D NMR experiments. This study is the first to report monoterpene glycosides with β-pinene aglycone in Aquifoliaceae. Nine of these compounds were evaluated in vitro for their anti-platelet aggregation activities. Among them, compounds 3 and 4 showed moderate inhibitory activities on ADP-induced blood platelet aggregation [inhibition (%): 32.3 and 33.6, respectively] as compared to aspirin. |
| Databáze: | OpenAIRE |
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