The significance of cathepsins, thrombin and aminopeptidase in diffuse interstitial lung diseases
| Autor: | Makoto Kimura, Akihito Hayashi, Keiko Sato, Junya Miyata, Shinsaku Otsuka, Kenji Tani, Tomoyuki Urata, Saburo Sone |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2005 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty cathepsin B cathepsin G Cathepsin G cathepsin H Aminopeptidases General Biochemistry Genetics and Molecular Biology Cathepsin B chemistry.chemical_compound Idiopathic pulmonary fibrosis Cathepsin H medicine Humans interstitial lung diseases Lymphocytes Aged Cathepsin aminopeptidase medicine.diagnostic_test business.industry General Medicine Middle Aged respiratory system medicine.disease Cathepsins thrombin respiratory tract diseases Bronchoalveolar lavage chemistry Case-Control Studies Immunology Female business Lung Diseases Interstitial Bronchoalveolar Lavage Fluid Hypersensitivity pneumonitis Cryptogenic Organizing Pneumonia Peptide Hydrolases |
| Zdroj: | The journal of medical investigation : JMI. 52(1-2):93-100 |
| ISSN: | 1343-1420 |
| Popis: | To determine the significance of proteases in interstitial lung diseases, we examined the activity of cathepsins, thrombin, and aminopeptidase in bronchoalveolar lavage (BAL) fluid from patients with these disorders. Significantly increased activities of cathepsin H and aminopeptidase were detected in BAL fluid from patients with idiopathic pulmonary fibrosis (IPF), cryptogenic organizing pneumonia (COP), chronic eosinophilic pneumonia (CEP) and hypersensitivity pneumonitis (HP). Significantly higher activity of cathepsin B was found in BAL fluid from patients with CEP. The activity of thrombin was significantly higher in patients with IPF and CEP. In patients with IPF, there were significant correlations between neutrophil number and the activity of cathepsin B, cathepsin H or aminopeptidase. In patients with COP and HP, the activity of the proteases was significantly higher in patients with higher number of lymphocytes than in those with lower number of lymphocytes. The present study suggests that the activity of the proteases is a useful marker in activity of the interstitial lung diseases, and may have a role in the pathogenesis of these disorders. |
| Databáze: | OpenAIRE |
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