Intestinal permeability parameters in obese patients are correlated with metabolic syndrome risk factors
| Autor: | Maria do Carmo Gouveia Peluzio, N.C.S. Souza, Tatiana Fiche Salles Teixeira, Célia Ferreira, Paula Garcia Chiarello, Josefina Bressan, Sylvia do Carmo Castro Franceschini |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Blood Glucose medicine.medical_specialty medicine.medical_treatment Blood Pressure Critical Care and Intensive Care Medicine COMPOSIÇÃO CORPORAL Permeability Excretion Young Adult chemistry.chemical_compound Lactulose High-density lipoprotein Insulin resistance Risk Factors Internal medicine medicine Humans Insulin Mannitol Obesity Metabolic Syndrome Nutrition and Dietetics Intestinal permeability business.industry Cholesterol HDL Fasting medicine.disease Intestines Endocrinology Intestinal Absorption chemistry Body Composition Female Metabolic syndrome business Body mass index medicine.drug |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 0261-5614 |
| Popis: | summary Background & aims: Altered intestinal permeability has been shown to be associated with metabolic alterations in animal models of obesity, but not in humans. The aim of this study was to assess intestinal permeability in obese women and verify if there is any association with anthropometric measurements, body composition or biochemical variables. Methods: Twenty lean and twenty obese females participated in the study. Anthropometric measurements, body composition and blood pressure were assessed and biochemical analyses were performed. Administration of lactulose and mannitol followed by their quantification in urine was used to assess the intestinal permeability of volunteers. Results: The obese group showed lower HDL (p < 0.05), higher fasting glucose, insulin, HOMA index and lactulose excretion than the lean group (p < 0.05), suggesting increased paracellular permeability. Lactulose excretion showed positive correlation (p < 0.05) with waist and abdominal circumference. Blood insulin and the HOMA index also increased with the increase in mannitol and lactulose excretion and in the L/M ratio (p < 0.05). L/M ratio presented a negative correlation with HDL concentration (p < 0.05). Conclusions: We demonstrated that intestinal permeability parameters in obese women are positively correlated with anthropometric measurements and metabolic variables. Therapeutic interventions focused onintestinehealthandthemodulationofintestinalpermeabilityshouldbeexploredinthecontextofobesity. |
| Databáze: | OpenAIRE |
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