Biosurfactants and anti-inflammatory activity: A potential new approach towards COVID-19
| Autor: | Sarathbabu Subbarayan, Abilash Valsala Gopalakrishnan, Raviminickam Thangarasu, Dhivya Venkatesan, Arul Narayanasamy, Vivekanandhan Govindasami, Siva Kamalakannan, Nachimuthu Senthil Kumar, Mahalaxmi Iyer, Ayan Roy, Balachandar Vellingiri, Mohana Devi Subramaniam |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
2019-20 coronavirus outbreak
Immunomodulatory Coronavirus disease 2019 (COVID-19) medicine.drug_class Health Toxicology and Mutagenesis Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Inflammatory response 0208 environmental biotechnology Microorganisms 02 engineering and technology 010501 environmental sciences Cytokine storm 01 natural sciences Anti-inflammatory Article medicine Environmental Chemistry Secretion 0105 earth and related environmental sciences chemistry.chemical_classification Reactive oxygen species Chemistry SARS-CoV-2 Biosurfactants (BSs) Public Health Environmental and Occupational Health medicine.disease 020801 environmental engineering Biochemistry |
| Zdroj: | Current Opinion in Environmental Science & Health |
| ISSN: | 2468-5844 |
| Popis: | Coronavirus Disease 2019 (COVID-19) has grown to be global public health emergency. The biosurfactants (BSs) are surface-active biomolecules with unique properties and wide applications. Several microbes synthesize secondary metabolites with surface-active properties which has wide range of anti-inflammatory and anti-viral role.. The monocytes and neutrophils are activated by bacteria which subsequently result in high secretion of pro-inflammatory cytokines (TNF-α, IL-6, IL-8, IL-12, Il-18 and IL-1β) and toll-like receptors-2 (TLR-2). Following the inflammatory response, BSs induce the production of cationic proteins, reactive oxygen species (ROS) and lysozyme, and thus can be utilized for therapeutic purposes. This review provides recent advances in the anti-inflammatory and antiviral activities of biosurfactants and discusses the potential use of these compounds against COVID-19, highlighting the need for in-vitro and in-vivo approaches to confirm this hypothesis. This suggestion is necessary because there are still no studies that have focused on the use of biosurfactants against COVID-19. |
| Databáze: | OpenAIRE |
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