Intussusception following rotavirus vaccine administration: post-marketing surveillance in the National Immunization Program in Australia
| Autor: | J P, Buttery, M H, Danchin, K J, Lee, J B, Carlin, P B, McIntyre, E J, Elliott, R, Booy, J E, Bines, Vicki, Krause |
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| Rok vydání: | 2010 |
| Předmět: |
Pediatrics
medicine.medical_specialty Population Postmarketing surveillance Vaccines Attenuated Risk Assessment Intussusception (medical disorder) medicine Product Surveillance Postmarketing Adverse Drug Reaction Reporting Systems Humans education education.field_of_study General Veterinary General Immunology and Microbiology business.industry Immunization Programs Public Health Environmental and Occupational Health Australia Rotavirus Vaccines Infant medicine.disease Rotavirus vaccine Vaccination Infectious Diseases Immunization Relative risk Molecular Medicine Risk assessment business Intussusception |
| Zdroj: | Vaccine. 29(16) |
| ISSN: | 1873-2518 |
| Popis: | Introduction: In Australia, post-marketing surveillance for intussusception following vaccination commenced with funding of RotaTeq(®) and Rotarix(®) vaccines under the National Immunization Program (NIP) in July 2007. Methods: Two active surveillance mechanisms (hospital-based case ascertainment and monthly reports from paediatricians) identified intussusception cases between 1st July 2007 and 31st December 2008 in four states. Linkage to vaccination records identified cases occurring within 1-7 and 1-21 days of rotavirus vaccination. Expected cases within the post-vaccination windows were calculated by applying rates of intussusception from national hospitalisation data over 6 years (mid-2000 to mid-2006), by age and state, to numbers vaccinated (by dose) according to the Australian Childhood Immunization Register. Results: Combining exposure windows associated with all doses of rotavirus vaccine from 1 to 9 months of age, there was no evidence of an increased risk of intussusception following vaccination for either vaccine. However, in infants 1 to |
| Databáze: | OpenAIRE |
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