Metabolic syndrome in women with previous gestational diabetes

Autor: Michael Festersen Nielsen, Ervin Kallfa, Karsten Kaiser, Greta Dubietyte, Finn Friis Lauszus
Rok vydání: 2021
Předmět:
Zdroj: Kaiser, K, Nielsen, M F, Kallfa, E, Dubietyte, G & Lauszus, F F 2021, ' Metabolic syndrome in women with previous gestational diabetes ', Scientific Reports, vol. 11, 11558 . https://doi.org/10.1038/s41598-021-90832-0
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
ISSN: 2045-2322
DOI: 10.1038/s41598-021-90832-0
Popis: To evaluate the incidence and timing of the diagnosis of metabolic syndrome in a cohort of Danish women after a pregnancy with gestational diabetes (GDM) to estimate the optimum time for preventative actions in relation to metabolic syndrome (MetS). In this follow-up study, 435 women were included from a consecutive cohort with prior history of GDM. Data on dyslipidemia, hypertension and other cardiovascular disorders (CVD) were extracted from the electronic patient journal. Any antidiabetic, cardiovascular and cholesterol-lowering medicine was ascertained in the national prescription database. Similarly, any blood test taken was evaluated. We defined a patient having MetS if the criteria of the WHO based definition of diabetes or impaired glucose regulation were met. Further, we added as alternative for glucose intolerance, a glycosylated hemoglobin (HbA1c) > 44 mmol/mol or the former level ≥ 6.5%. Further, dyslipidemia, lipid lowering medications, BMI > 30 kg/m2 or antihypertensive treatment were used. For MetS outcome, diagnosis or medication for CVD was registered. All women were followed for median 5.7 years (range 0; 9). The incidence of MetS was 28%. Thirteen percent of these qualified already within one year after pregnancy for the diagnosis of MetS. Postpartum MetS was detected after a median of 3 years (range 0; 7 years); further, 36 (8%) had been diagnosed with manifest diabetes after pregnancy. The diagnosis of postpartum MetS was strongly associated with the prevalence of manifest diabetes. Six years after pregnancy the rate of metabolic syndrome was more than tripled (25 vs. 89%, no DM vs manifest DM, RR: 6.7; 95% CI 2.7–17, p
Databáze: OpenAIRE
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