Estriol Induced Squamous Metaplasia on the Nasal Mucosa in Patients with Hereditary Hemorrhagic Telangiectasia
| Autor: | l Karl Hormann, Haneen Sadick, Ramin Naim, Jasmina Oulmi-Kagermann, Frank Riedel, Wolfgang Bergler, Maliha Sadick |
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| Rok vydání: | 2005 |
| Předmět: |
Male
Pathology medicine.medical_specialty Administration Topical Biopsy Mucous membrane of nose Ointments otorhinolaryngologic diseases Humans Medicine Telangiectasia reproductive and urinary physiology Nose Metaplasia medicine.diagnostic_test Estriol business.industry Ciliated columnar epithelium General Medicine Middle Aged medicine.disease Epithelium Squamous metaplasia Nasal Mucosa medicine.anatomical_structure Female Telangiectasia Hereditary Hemorrhagic medicine.symptom business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Archives of Medical Research. 36:468-473 |
| ISSN: | 0188-4409 |
| DOI: | 10.1016/j.arcmed.2005.03.037 |
| Popis: | Background The aim of this study was to evaluate by light and electron microscopy the effect of topical estriol on the nasal mucosa in patients with hereditary hemorrhagic telangiectasia (HHT). Methods Twelve patients were instructed to apply twice daily 0.1% estriol as a nose ointment over a period of 12 months. Written consent was obtained from each patient, allowing biopsy specimens of the nasal mucosa to be taken prior to and 3, 6 and 12 months after estriol application. Results Metaplastic change of the nasal mucosa was observed 6 months after topical estriol application. The former ciliated columnar epithelium changed into a keratinizing squamous epithelium. The effect was reversible after discontinuation of estriol application. Conclusions For the first time, we could outline the effect of topical estriol on the nasal mucosa. These histomorphological findings, and the fact that estriol is a low-potency metabolite of estradiol, make estriol a valuable agent in the treatment of HHT patients. |
| Databáze: | OpenAIRE |
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