Mechanisms of Chemotherapy-Induced Neurotoxicity
| Autor: | Halina Was, Agata Borkowska, Ana Bagues, Longlong Tu, Julia Y. H. Liu, Zengbing Lu, John A. Rudd, Kulmira Nurgali, Raquel Abalo |
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| Přispěvatelé: | National Science Centre (Poland), European Commission, Ministerio de Ciencia, Innovación y Universidades (España) |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Frontiers in pharmacology. 13 |
| ISSN: | 1663-9812 |
| Popis: | Since the first clinical trials conducted after World War II, chemotherapeutic drugs have been extensively used in the clinic as the main cancer treatment either alone or as an adjuvant therapy before and after surgery. Although the use of chemotherapeutic drugs improved the survival of cancer patients, these drugs are notorious for causing many severe side effects that significantly reduce the efficacy of anti-cancer treatment and patients’ quality of life. Many widely used chemotherapy drugs including platinum-based agents, taxanes, vinca alkaloids, proteasome inhibitors, and thalidomide analogs may cause direct and indirect neurotoxicity. In this review we discuss the main effects of chemotherapy on the peripheral and central nervous systems, including neuropathic pain, chemobrain, enteric neuropathy, as well as nausea and emesis. Understanding mechanisms involved in chemotherapy-induced neurotoxicity is crucial for the development of drugs that can protect the nervous system, reduce symptoms experienced by millions of patients, and improve the outcome of the treatment and patients’ quality of life. HW is supported by Sonata Bis 7 grant no. 2017/26/E/NZ3/00434 from the National Science Centre, Poland and intramural grant no. 1/8971(500) from Military Institute of Medicine. AgB is the recipient of a scholarship from Postgraduate School of Molecular Medicine funded by European Union resources under the European Social Fund - Operational Program Knowledge, Education and Development under the project “Program of Interdisciplinary Doctoral Studies using new generation sequencing (NGS) in personalized medicine”. RA research is supported by Ministerio de Ciencia, Innovación y Universidades, Spain (PID2019-111510RB-I00). |
| Databáze: | OpenAIRE |
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