Safety, Mortality, and Hemodynamic Impact of Patients with MitraClip Undergoing Left Ventricular Assist Device Implantation
| Autor: | Michiel Morshuis, Sebastian V. Rojas, Henrik Fox, Takayuki Gyoten, Jan Gummert, Marcus-André Deutsch, René Schramm, Volker Rudolph |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Ventricular Dysfunction Right medicine.medical_treatment Cardiac index Pharmaceutical Science Hemodynamics Internal medicine Genetics medicine Humans Pulmonary Wedge Pressure Cardiac Surgical Procedures Pulmonary wedge pressure Genetics (clinical) Retrospective Studies Heart Failure business.industry MitraClip Perioperative medicine.disease Treatment Outcome Ventricular assist device Heart failure Cardiology Molecular Medicine Heart-Assist Devices Cardiology and Cardiovascular Medicine business Percutaneous Mitral Valve Repair |
| Zdroj: | Journal of Cardiovascular Translational Research. 15:676-686 |
| ISSN: | 1937-5395 1937-5387 |
| DOI: | 10.1007/s12265-021-10178-w |
| Popis: | The interactions and hemodynamic impact of transcatheter percutaneous mitral valve repair (TMR) have not yet been investigated in patients undergoing left ventricular assist device (LVAD) implantation, but hemodynamic adverse effects are feared in the combination of TMR and LVAD for altered mitral valve flow. This study investigated the hemodynamic interplay in combination of TMR and LVAD in 119 patients, and propensity score match analysis revealed no difference in both perioperative mortality and 2-year follow-up survival (p = 0.84). Nonetheless, postoperatively mean pulmonary arterial pressure, pulmonary capillary wedge pressure, and cardiac index improved, and multivariable cox regression analysis at 2 years identified preoperative total bilirubin and temporary right ventricular mechanical circulatory support as independent risk factors for all-cause mortality but not TMR. Prior TMR has no impact on mortality or cardiovascular complications in patients with LVAD. Graphical abstract |
| Databáze: | OpenAIRE |
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