Gelatin Microspheres: Correlation between Embolic Effect/Degradability and Cross-linkage/Particle Size
| Autor: | Akinaga Sonoda, Hideji Otani, Masashi Takahashi, Atsuko Yamamoto, Kiyoshi Murata, Yuki Tomozawa, Ayumi Nitta-Seko, Norihisa Nitta, Shinichi Ohta, Keiko Tsuchiya, Shobu Watanabe |
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| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Cross-linkage medicine.medical_treatment Kidney Sensitivity and Specificity Random Allocation Renal Artery Animals Medicine Radiology Nuclear Medicine and imaging Embolization Right Renal Artery Particle Size medicine.diagnostic_test business.industry Biopsy Needle Ultrasound Angiography Embolization Therapeutic Immunohistochemistry Microspheres Surgery Disease Models Animal medicine.anatomical_structure Gelatin microspheres Gelatin Female Rabbits Particle size Cardiology and Cardiovascular Medicine business Nuclear medicine Artery |
| Zdroj: | CardioVascular and Interventional Radiology. 36:1105-1111 |
| ISSN: | 1432-086X 0174-1551 |
| Popis: | To evaluate the embolic effect and degradability of gelatin microspheres (GMS) using various degrees of cross-linkage and particle sizes in rabbit renal artery embolization. Four types of GMS were used, as follows: 2 types of cross-linkage and 2 types of particle size. Twenty-four rabbits (6 in each group) were used for the renal artery embolization. Renal angiography was performed before and after embolization of right renal artery. Follow-up renal angiography was performed 2 days (n = 2), 5 days (n = 2), and 15 days (n = 2) after embolization in each group, and then kidneys were removed for histopathological evaluation. Vascular areas of the angiography were measured by Image J software, and the reperfusion rate was calculated. In renal specimens, residual GMS were checked and the degree of degradation was classified according to a 4-point scale. The mean amounts of large- and small-particle-size GMS injected were 15.0 and 34.3 mg, respectively. Tissue necrosis was confirmed in each group; however, no difference was observed among groups. Renal reperfusion was observed more with small GMS than with large GMS. Renal reperfusion was also observed more with low cross-linked GMS than with high cross-linked GMS. In histopathological specimens, large GMS were confirmed in lobar artery, and small GMS were confirmed in lobular artery. Low cross-linked GMS completely degraded 15 days after embolization. In contrast, high cross-linked GMS were persistent 15 days after embolization. Degree of cross-linkage and particle size affected degradability and reperfusion. |
| Databáze: | OpenAIRE |
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