Postoperative Survival in Colitis-associated Colorectal Cancer With Ulcerative Colitis in Japan: A Multicenter Analysis
| Autor: | Tsuneo Iiai, Yuuji Funayama, Kitaro Futami, Hiroki Ikeuchi, Akira Sugita, Yasuo Suzuki, Michio Itabashi |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Adolescent Colorectal cancer medicine.medical_treatment Inflammatory bowel disease Gastroenterology Disease-Free Survival Young Adult Japan Risk Factors Internal medicine Surveys and Questionnaires medicine Humans Postoperative Period Colitis Child Aged Proportional Hazards Models Aged 80 and over Proportional hazards model Proctocolectomy business.industry Proctocolectomy Restorative Cancer General Medicine Middle Aged medicine.disease Ulcerative colitis Oncology Colitis Ulcerative Female Segmental resection business Colorectal Neoplasms |
| Zdroj: | Anticancer research. 41(5) |
| ISSN: | 1791-7530 |
| Popis: | Background/aim The aim of the study was to analyze the postoperative survival of colitis-associated colorectal cancer (CAC) with ulcerative colitis (UC), and the risk factors affecting it. Patients and methods A questionnaire including postoperative survival was sent to 88 hospitals that reported CAC patients in the literature up until January, 2006 and to members of the Research Group of Intractable Inflammatory Bowel Disease. Results The 5-year postoperative overall survival (OS) of 170 CAC patients was 74.2% which was similar to sporadic colorectal cancer in Japan (72.1%). Pathologic TNM stage, histological type, type of surgical procedure (proctocolectomy, segmental resection), and preoperative cancer surveillance were statistically significant factors for OS. By Cox regression analysis, pathologic TNM stage and proctocolectomy were statistically significant prognostic factors for OS. Conclusion In CAC with UC, the postoperative OS was similar to sporadic colorectal cancer. Pathologic TNM stage and proctocolectomy were confirmed as important prognostic factors. |
| Databáze: | OpenAIRE |
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