A Review on Mechanisms of Anti Tumor Activity of Chalcones
| Autor: | Anukriti Khare, Rishi Kodwani, Bornika Roy, Rahul Sharma, Rakesh Kumar, Jennifer Thomas, Sukriti Kapoor, Rajendra Phartyal, Sanjay Kumar, Sandhya Singh, Shukla Saluja, Ritu Bansal, Sonali Khurana |
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| Rok vydání: | 2015 |
| Předmět: |
Drug
Cancer Research Cell cycle checkpoint medicine.drug_class media_common.quotation_subject Biology Pharmacology Anti-inflammatory Structure-Activity Relationship Chalcones Tubulin medicine Animals Humans Structure–activity relationship Cytotoxicity Cell Proliferation media_common Dose-Response Relationship Drug Cell Cycle Antineoplastic Agents Phytogenic Drug development Apoptosis Molecular Medicine Drug Screening Assays Antitumor Pharmacophore |
| Zdroj: | Anti-Cancer Agents in Medicinal Chemistry. 16:200-211 |
| ISSN: | 1871-5206 |
| DOI: | 10.2174/1871520615666150518093144 |
| Popis: | Chalcones comprise a characteristic framework of 1, 3-diaryl-2-propen-1-one. They have been heralded as promising anti cancer drugs and have received much attention in the field of cancer research and drug development. The cytotoxicity of these potent pharmacophores is attributable to a wide spectrum of biological activities like anti inflammatory, anti proliferative, anti fungal, etc. These anti tumor activities are effectuated through apoptosis, cell cycle arrest, anti tubulin and so forth. This review summarizes the recent developments on anti tumor activity of synthetic and natural chalcones and their detailed underlying mechanisms as reported in the past. |
| Databáze: | OpenAIRE |
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