Denervation leads to volume regression in breast cancer
| Autor: | Arne Fischmann, Patricia E. Engels, Srinivas Madduri, Stefanie von Felten, Elisabeth A. Kappos, Daniel F. Kalbermatten, Dirk J. Schaefer, Moritz Meyer zu Schwabedissen, Patricia K. Sieber, Mathias Tremp |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Nervous system medicine.medical_specialty Urology Breast Neoplasms Surgical Flaps Rats Sprague-Dawley 03 medical and health sciences 0302 clinical medicine Breast cancer In vivo Cell Line Tumor medicine Animals Humans Peripheral Nerves Tumor growth Denervation medicine.diagnostic_test business.industry Histology Magnetic resonance imaging medicine.disease Magnetic Resonance Imaging Surgery Peripheral Rats Tumor Burden 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Cancer cell Tumor–nerve interaction Female business Neoplasm Transplantation MRI |
| Zdroj: | Journal of Plastic, Reconstructive & Aesthetic Surgery, Vol. 71, No 6 (2018) pp. 833-839 |
| ISSN: | 1878-0539 1748-6815 |
| Popis: | The nervous system plays a key role in controlling the dynamic functions of multicellular complex organisms. Although peripheral nerves are supposed to play a pivotal role in tumor growth and dissemination, little experimental evidence exists to date. We assessed the effect of denervation on breast cancer growth by magnetic resonance imaging (MRI) in rats. Human breast cancer cells were implanted into adipofascial flaps with intact or surgically excised supplying nerve. Tumor volumes were measured 2 and 8 weeks after implantation by in vivo MRI. Results were validated by histology. Postoperative tumor volumes at 2 and 8 weeks were reduced by 76% (95% CI: 22-93%) in the denervated groups. Tumor area as determined histologically was reduced by 70% (95% CI: 60-78%). Thus, peripheral denervation may be an effective surgical approach for the palliative treatment of locally progressing or uncontrollable breast cancer. |
| Databáze: | OpenAIRE |
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