Low-dose aspirin for in vitro fertilization or intracytoplasmic sperm injection: a systematic review and a meta-analysis of the literature
| Autor: | Francesco Dentali, Walter Ageno, Elvira Grandone, Saskia Middeldorp, Elena Rancan, Alessandro Squizzato, Maurizio Margaglione, Emanuele Rezoagli |
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| Přispěvatelé: | ACS - Amsterdam Cardiovascular Sciences, Vascular Medicine, Dentali, F, Ageno, W, Rezoagli, E, Rancan, E, Squizzato, A, Middeldorp, S, Margaglione, M, Grandone, E |
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male medicine.medical_specialty Pregnancy Rate medicine.medical_treatment Fertilization in Vitro Intracytoplasmic sperm injection Miscarriage law.invention Fertility Agents Randomized controlled trial law Pregnancy medicine Abortion Spontaneou Odds Ratio Humans Embryo Implantation Sperm Injections Intracytoplasmic MED/41 - ANESTESIOLOGIA Fertility Agent Aspirin In vitro fertilisation business.industry Obstetrics Hematology medicine.disease Abortion Spontaneous Pregnancy rate Female Live birth business Live Birth medicine.drug Human |
| Zdroj: | Journal of thrombosis and haemostasis, 10(10), 2075-2085. Wiley-Blackwell |
| ISSN: | 1538-7933 |
| Popis: | Summary. Background: It was hypothesized that low-dose aspirin could improve implantation rates in subsequent pregnancies in women undergoing in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI). Previous studies have shown inconclusive results or focused on surrogate endpoints. We therefore conducted a systematic review and meta-analysis of the literature investigating the effect of low-dose aspirin on hard outcomes, including live birth rate, pregnancy rate and miscarriage. Methods: MEDLINE and EMBASE databases were searched up to November 2011. Randomized controlled trials comparing low-dose aspirin with placebo/no treatment in IVF/ICSI women were included. Pooled odds ratios (ORs) and 95%confidence intervals (CIs) were calculated. Results: Seventeen studies with 6403 patients were included. The use of aspirin did not improve live birth pregnancy rate compared with placebo or no treatment (1.08; 95% CI, 0.90, 1.29). Pregnancy rates were significantly increased in patients randomized to low-dose aspirin (OR, 1.19; 95% CI, 1.01, 1.39), but miscarriage rates were not (OR, 1.18; 95% CI, 0.82, 1.68). Results of sensitivity analyses including high-quality studies did not show statistically significant differences in all considered endpoints. Conclusions: The results of this study do not show a substantial efficacy of aspirin inwomen undergoing IVF/ICSI and do not support the use of low-dose aspirin to improve the success of IVF/ICSI in terms of pregnancy outcomes. Further high-quality studies evaluating the possible efficacy of aspirin in selected groups of patients are warranted. |
| Databáze: | OpenAIRE |
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