Thiol/disulfide homeostasis and its relationship with insulin resistance in patients with rosacea
| Autor: | Duygu Yazgan Aksoy, Suzan Demir Pektas, Ahmet Kara, Nese Cinar, Deniz Duman, Gulhan Akbaba, Salim Neselioglu, Gökhan Pektaş, Hilal Semra Hancer, Ozcan Erel |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Dermatology medicine.disease_cause Pathogenesis Insulin resistance Internal medicine medicine Homeostasis Humans Disulfides Prospective Studies Sulfhydryl Compounds Prospective cohort study business.industry Metabolic disorder food and beverages medicine.disease Oxidative Stress Endocrinology Rosacea Chronic Disease Insulin Resistance business Body mass index Biomarkers Oxidative stress |
| Zdroj: | Journal of Cosmetic Dermatology. 21:2655-2661 |
| ISSN: | 1473-2165 1473-2130 |
| DOI: | 10.1111/jocd.14477 |
| Popis: | Rosacea is a chronic inflammatory cutaneous disease that can be associated with cardiometabolic disorders. Oxidative stress is included in the pathogenesis of rosacea, and thiol-disulfide homeostasis (TDH) acts as antioxidants.To evaluate the TDH and metabolic parameters in patients with rosacea.A total of 42 rosacea patients and 50 controls participated in this prospective study. Demographic data, clinical entities, anthropometric measurements, and laboratory findings were recorded. Additionally, TDH was measured by an automated spectrophotometric method.Rosacea patients had greater body mass index values (27.9 ± 5.2 kg/m² vs. 23 ± 1.4 kg/m², p 0.001), waist-hip ratios (0.87 ± 0.1 vs. 0.77 ± 0.8, p 0.001), and insulin resistance (3.0 ± 2.0 vs. 1.3 ± 0.5, p 0.001) compared with controls. Disulfide levels, the disulfide/native thiol ratio (DNTR), and the disulfide/total thiol ratio (DTTR) were increased (p 0.05) in rosacea patients. Native thiol and total thiol levels and the native/total thiol ratio (NTTR) were decreased in rosacea patients (p 0.05). Different rosacea subtypes had no effect on oxidative stress markers. The duration of illness and insulin resistance values significantly correlated with DNTR and DTTR in the rosacea group (p 0.05).Rosacea has a metabolic milieu with increased oxidative stress and insulin resistance. |
| Databáze: | OpenAIRE |
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